{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:51Z","timestamp":1756339611793,"version":"3.44.0"},"reference-count":3,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,28]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Multisystem inflammatory syndrome in adults (MIS-A) has been reported as a rare but severe consequence of COVID-19 infection. Adult patients were more likely to present with hypotension and cardiac illness when compared with multisystem inflammatory syndrome in children. Although the exact prevalence of MIS-A is unknown, more cases have been observed in men and younger adults. The pathophysiology of MIS-A is also unclear, but is thought to be caused by a delayed, dysregulated immune response. Given no established guideline for treatment of MIS-A, treatment has been based on case reports. We present a case of MIS-A in a woman in her 60s who had severe hypotension, progressive dyspnoea, massive pleural effusion, hypoxaemia, thyroiditis and multiple organ failure, which dramatically improved after treatment with corticosteroid and interleukin 6 inhibitor.<\/jats:p>","DOI":"10.1136\/bcr-2021-248520","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:56:13Z","timestamp":1653310573000},"page":"e248520","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment"],"prefix":"10.1136","volume":"15","author":[{"given":"Thitirat","family":"Rojnukoolwanich","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Services, Bumrungrad International Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chankanok","family":"Kuagoolwongse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bumrungrad International Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asda","family":"Vibhagool","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bumrungrad International Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-9761","authenticated-orcid":false,"given":"Krit","family":"Pongpirul","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand"},{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"},{"name":"Clinical Research Center, Bumrungrad International Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2025082712244654000_15.5.e248520.1","doi-asserted-by":"crossref","unstructured":"Morris SB , Schwartz NG , Patel P , et al . Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection \u2014 United Kingdom and United States, March\u2013August 2020. MMWR Morb Mortal Wkly Rep;69:1450\u20136.doi:10.15585\/mmwr.mm6940e1","DOI":"10.15585\/mmwr.mm6940e1"},{"key":"2025082712244654000_15.5.e248520.2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.26456","article-title":"Clinical characteristics of multisystem inflammatory syndrome in adults: a systematic review","volume":"4","author":"Patel","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2025082712244654000_15.5.e248520.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04843-1"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-248520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:24:54Z","timestamp":1756322694000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-248520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":3,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,10]]},"published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1136\/bcr-2021-248520"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-248520","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}