{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:32Z","timestamp":1756339352650,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,2,11]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Tumour to tumour metastases are uncommon, and we report a case of carotid body paraganglioma metastatic to a hepatocellular adenoma. A 54-year-old man presented after a CT chest for chronic cough that incidentally identified two liver lesions in segment 3 and caudate. The imaging findings were suspicious for atypical haemangiomas versus hepatocellular adenoma. The segment 3 lesion was biopsied, demonstrating beta-catenin activated hepatocellular adenoma. He underwent partial hepatectomy with pathology showing the beta-catenin activated hepatocellular adenoma contained a central area of paraganglioma. On closer review, the patient revealed a carotid body paraganglioma with lymph node metastases requiring resection 24 years earlier. He subsequently underwent left hepatectomy including the resection bed and caudate, which confirmed the caudate lesion as metastatic paraganglioma. This case demonstrates how paraganglioma can metastasise to liver decades after initial resection and provide insight into the diagnostic workup for hepatocellular adenoma with neuroendocrine features.<\/jats:p>","DOI":"10.1136\/bcr-2021-248527","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:07:49Z","timestamp":1646219269000},"page":"e248527","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Tumour to tumour metastasis: case of a carotid body paraganglioma metastatic to a hepatocellular adenoma"],"prefix":"10.1136","volume":"15","author":[{"given":"Nicole","family":"Jedrzejko","sequence":"first","affiliation":[{"name":"Surgery, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra B","family":"Berg","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananta","family":"Gurung","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Surgery, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"2025082623521069000_15.3.e248527.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O"},{"key":"2025082623521069000_15.3.e248527.2","doi-asserted-by":"publisher","DOI":"10.1177\/106689690301100214"},{"key":"2025082623521069000_15.3.e248527.3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/13651820310020846","article-title":"Hepatic adenomas in male patients","volume":"6","author":"Ronald","year":"2004","journal-title":"HPB"},{"key":"2025082623521069000_15.3.e248527.4","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-019-1061-6","article-title":"Hepatic metastatic paraganglioma 12\u2009years after retroperitoneal paraganglioma resection: a case report","volume":"19","author":"Dong","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"2025082623521069000_15.3.e248527.5","first-page":"759","article-title":"First report of hepatic lobectomy for metastatic carotid body tumor","volume":"41","author":"Mall","year":"2000","journal-title":"J Cardiovasc Surg"},{"key":"2025082623521069000_15.3.e248527.6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.anorl.2013.05.003","article-title":"Malignant head\/neck paragangliomas. Comparative study","volume":"131","author":"Mediouni","year":"2014","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"2025082623521069000_15.3.e248527.7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/000313481307900507","article-title":"Hepatic metastasis of a carotid body paraganglioma 5 years after resection of the primary tumor","volume":"79","author":"Moris","year":"2013","journal-title":"Am Surg"},{"key":"2025082623521069000_15.3.e248527.8","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010293","article-title":"Primary functioning hepatic paraganglioma mimicking hepatocellular carcinoma","volume":"97","author":"Liao","year":"2018","journal-title":"Medicine"},{"key":"2025082623521069000_15.3.e248527.9","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.14443","article-title":"Hepatobiliary and pancreatic: tumor to tumor metastasis from a primary insulinoma to a hepatic adenoma","volume":"34","author":"Xu","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"2025082623521069000_15.3.e248527.10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21068"},{"key":"2025082623521069000_15.3.e248527.11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.path.2018.02.007","article-title":"Hepatic adenomas: classification, controversies, and consensus","volume":"11","author":"Torbenson","year":"2018","journal-title":"Surg Pathol Clin"},{"key":"2025082623521069000_15.3.e248527.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.222109"},{"key":"2025082623521069000_15.3.e248527.13","unstructured":"Amin MB , Edge SB , Greene FL , et al , eds. AJCC Cancer Staging Manual. 8th ed. New York: Springer, 2017."},{"key":"2025082623521069000_15.3.e248527.14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12020-021-02854-3","article-title":"Assessment of the AJCC staging system of pheochromocytomas\/paragangliomas","volume":"75","author":"Abdel-Rahman","year":"2022","journal-title":"Endocrine"},{"key":"2025082623521069000_15.3.e248527.15","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/1097-0142(197812)42:6<2865::AID-CNCR2820420648>3.0.CO;2-Y","article-title":"Soft tissue metastasis of a chemodectoma. A case report and review of the literature","volume":"42","author":"Rangwala","year":"1978","journal-title":"Cancer"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-248527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:52:18Z","timestamp":1756277538000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-248527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,2]]},"published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1136\/bcr-2021-248527"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-248527","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}