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In our case series, the mean cumulative dose of prednisolone was 1156.5\u2009mg (900\u20131413\u2009mg), which is less than the cumulative dose reported in literature for osteonecrosis of the knee. In our case series, the patients developed symptomatic osteonecrosis at a mean interval of 73 days after initiation of steroid therapy, with the earliest presenting at 25 days. Early diagnosis of osteonecrosis of the knee on high clinical suspicion by MRI would help in early intervention with bisphosphonate therapy.<\/jats:p>","DOI":"10.1136\/bcr-2021-248583","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:04:55Z","timestamp":1648555495000},"page":"e248583","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Secondary osteonecrosis of the knee as a part of long COVID-19 syndrome: a case series"],"prefix":"10.1136","volume":"15","author":[{"given":"Sanjay R","family":"Agarwala","sequence":"first","affiliation":[{"name":"Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Vijayvargiya","sequence":"additional","affiliation":[{"name":"Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Sawant","sequence":"additional","affiliation":[{"name":"Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"2025082802465458000_15.3.e248583.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01900-0"},{"key":"2025082802465458000_15.3.e248583.2","unstructured":"Overview | COVID-19 rapid guideline: managing the long-term effects of COVID-19 | guidance | NICE. 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