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ARN is usually caused by an acute infection by either varicella zoster virus or herpes simplex virus, rarely cytomegalovirus (CMV). ARN often occurs in healthy adults; occasionally affecting immunocompromised patients with poor prognosis including significant visual loss and detachment of the atrophic retina regardless of antiviral treatment. We presented a man in his early 30s with a history of left eye floaters and blurred vision. He was diagnosed with T-cell acute lymphoblastic leukaemia 1\u2009year ago and treated with chemotherapy and allogenic haematopoietic stem cell transplant 5\u2009months ago. His clinical diagnosis was left eye ARN caused by acute viral infection with CMV being the most likely cause, which is rarely seen in immunocompromised patients. Our case highlighted a diagnostic and therapeutic challenge in the absence of guideline or evidence-based literature to follow.<\/jats:p>","DOI":"10.1136\/bcr-2021-248636","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:06:41Z","timestamp":1646219201000},"page":"e248636","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Rare cause of left eye floaters and blurred vision in an immunocompromised patient: acute retinal necrosis (ARN)"],"prefix":"10.1136","volume":"15","author":[{"given":"Xia","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleo","family":"Wee","sequence":"additional","affiliation":[{"name":"Curtin Medical School, Curtin University Bentley Campus, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-1111","authenticated-orcid":false,"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Curtin Medical School, Curtin University Bentley Campus, Perth, Western Australia, Australia"},{"name":"Medical Education & General Practice, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengxia","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"2025082623530714000_15.3.e248636.1","first-page":"607","article-title":"Unilateral acute uveitis with periarteritis and detachment","volume":"25","author":"Urayama","year":"1971","journal-title":"Japan J Ophthalmol"},{"key":"2025082623530714000_15.3.e248636.2","first-page":"38","article-title":"Diagnosing and managing acute retinal necrosis","volume":"10","author":"Wong","year":"2013","journal-title":"Retinal Physician"},{"key":"2025082623530714000_15.3.e248636.3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/eye.2011.338","article-title":"Acute retinal necrosis in the United Kingdom: results of a prospective surveillance study","volume":"26","author":"Cochrane","year":"2012","journal-title":"Eye"},{"key":"2025082623530714000_15.3.e248636.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.114884"},{"key":"2025082623530714000_15.3.e248636.5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-227290","article-title":"Acute retinal necrosis (Arn) following chickenpox in a patient of Vogt-Koyanagi-Harada (VKH) syndrome using immunosuppressants","volume":"11","author":"Gupta","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082623530714000_15.3.e248636.6","unstructured":"Bergstrom R , Tripathy K . 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