{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:47:29Z","timestamp":1773028049716,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,9,25]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>A term Caucasian neonate with an uncomplicated birth history presented with persistent umbilical stump bleeding unresponsive to extensive topical haemostatic measures initially. He subsequently developed hypovolaemic shock. Routine full blood count and basic coagulation screen were unremarkable. He received packed red cell and cryoprecipitate transfusions. Further specialist coagulation studies performed revealed factor XIII deficiency. Genetic investigations demonstrated a compound heterozygosity for the disorder. He was later started on monthly prophylactic treatment of plasma-derived factor XIII. Clinicians should have a high index of suspicion for factor XIII deficiency for newborns with abnormal umbilical stump bleeding in the presence of no bleeding risk factors and normal routine blood investigations.<\/jats:p>","DOI":"10.1136\/bcr-2022-248743","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T12:02:24Z","timestamp":1665144144000},"page":"e248743","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Delayed and prolonged umbilical stump bleeding in a Caucasian newborn as a presenting feature of factor XIII deficiency"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-5051","authenticated-orcid":false,"given":"David Boon Ngan","family":"Lim","sequence":"first","affiliation":[{"name":"Paediatrics, Frimley Health NHS Foundation Trust, Camberley, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mangles","sequence":"additional","affiliation":[{"name":"Haematology, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruna","family":"Goturu","sequence":"additional","affiliation":[{"name":"Paediatrics, Frimley Health NHS Foundation Trust, Camberley, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"2025082722191196000_15.10.e248743.1","first-page":"164","article-title":"Current understanding in diagnosis and management of factor XIII deficiency","volume":"3","author":"Naderi","year":"2013","journal-title":"Iran J Ped Hematol Oncol"},{"key":"2025082722191196000_15.10.e248743.2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1664-1"},{"key":"2025082722191196000_15.10.e248743.3","doi-asserted-by":"crossref","unstructured":"Batsuli G , Meeks SL . Chapter 116 \u2013 Factor XIII, \u03b12-Antiplasmin, and Plasminogen Activator Inhibitor-1 Deficiencies. In: Shaz BH , Hillyer CD , Gil MR , eds. Transfusion medicine and hemostasis. 3rd edn. Elsevier, 2019: 707\u201310.","DOI":"10.1016\/B978-0-12-813726-0.00116-1"},{"key":"2025082722191196000_15.10.e248743.4","doi-asserted-by":"crossref","unstructured":"Schmaier AH . Chapter 9 \u2013 Overview of Hemostasis. In: Schmaier AH , Hillard LM , eds. Concise guide to hematology. 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