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A variety of non-invasive methods to manage such lesions include conservative root canal treatment, aspiration-irrigation technique, decompression technique, calcium hydroxide therapy, lesion sterilisation and tissue repair therapy, and the apexum procedure. We present a case report describing non-surgical management of a large periapical lesion associated with a permanent central incisor displaying internal inflammatory resorption using platelet rich fibrin (PRF), bone graft and mineral trioxide aggregate (MTA).<\/jats:p>","DOI":"10.1136\/bcr-2022-248907","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T13:11:00Z","timestamp":1663333860000},"page":"e248907","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Non-surgical management of a large periapical lesion with internal resorption using PRF, hydroxyapatite and MTA"],"prefix":"10.1136","volume":"15","author":[{"given":"Geetika","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-0676","authenticated-orcid":false,"given":"Abhilasha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroz Alam","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"2025082723135915000_15.9.e248907.1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0030-4220(72)90325-8","article-title":"Nonsurgical resolution of radicular cysts","volume":"34","author":"Bhaskar","year":"1972","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2025082723135915000_15.9.e248907.2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0030-4220(68)90163-1","article-title":"The frequency and distribution of periapical cysts and granulomas. an evaluation of 800 specimens","volume":"25","author":"Lalonde","year":"1968","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2025082723135915000_15.9.e248907.3","unstructured":"Nair P . 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