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Survival rates for SCLS are very poor without treatment, so it is crucial for clinicians to recognise this disorder. A middle-aged woman who presented with generalised malaise and anasarca after receiving the BNT162b2 COVID-19 vaccine was diagnosed with SCLS. Treatment with methylprednisolone and intravenous immunoglobulin was commenced and her symptoms resolved. We expect that this case report will add to the existing literature on this rare disorder and the side effects of vaccinations.<\/jats:p>","DOI":"10.1136\/bcr-2022-248927","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T12:32:07Z","timestamp":1647347527000},"page":"e248927","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Systemic capillary leak syndrome (SCLS) after receiving BNT162b2 mRNA COVID-19 (Pfizer-BioNTech) vaccine"],"prefix":"10.1136","volume":"15","author":[{"given":"Masatoshi","family":"Inoue","sequence":"first","affiliation":[{"name":"Nephrology, Tajimi Hospital, Tajimi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yasue","sequence":"additional","affiliation":[{"name":"Nephrology, Tajimi Hospital, Tajimi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Nephrology, Tajimi Hospital, Tajimi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Nephrology, Tajimi Hospital, Tajimi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"2025082622494933000_15.3.e248927.1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jaip.2017.07.021","article-title":"Clinical presentation, management, and prognostic factors of idiopathic systemic capillary leak syndrome: a systematic review","volume":"6","author":"Eo","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082622494933000_15.3.e248927.2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jaci.2016.10.042","article-title":"Idiopathic systemic capillary leak syndrome (Clarkson disease)","volume":"140","author":"Druey","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025082622494933000_15.3.e248927.3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/CCM.0000000000002496","article-title":"The clinical picture of severe systemic Capillary-Leak syndrome episodes requiring ICU admission","volume":"45","author":"Pineton de Chambrun","year":"2017","journal-title":"Crit Care Med"},{"key":"2025082622494933000_15.3.e248927.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00272-6"},{"key":"2025082622494933000_15.3.e248927.5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3851\/IMP2989","article-title":"Influenza A virus infection is associated with systemic capillary leak syndrome: case report and systematic review of the literature","volume":"21","author":"Sousa","year":"2016","journal-title":"Antivir Ther"},{"key":"2025082622494933000_15.3.e248927.6","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-226108","article-title":"Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection","volume":"29","author":"Ebdrup","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082622494933000_15.3.e248927.7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-153-2-201007200-00005"},{"key":"2025082622494933000_15.3.e248927.8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/03009742.2021.1917145","article-title":"Systemic capillary leak syndrome triggered by SARS-CoV2 infection: case report and systematic review","volume":"51","author":"Beber","year":"2022","journal-title":"Scand J Rheumatol"},{"key":"2025082622494933000_15.3.e248927.9","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3201\/eid2710.211155","article-title":"Fatal exacerbations of systemic capillary leak syndrome complicating coronavirus disease","volume":"27","author":"Cheung","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"2025082622494933000_15.3.e248927.10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/jlb.60.5.563","article-title":"Regulation of cytokine and cytokine receptor expression by glucocorticoids","volume":"60","author":"Almawi","year":"1996","journal-title":"J Leukoc Biol"},{"key":"2025082622494933000_15.3.e248927.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.11.029"},{"key":"2025082622494933000_15.3.e248927.12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31817d7c71"},{"key":"2025082622494933000_15.3.e248927.13","doi-asserted-by":"crossref","first-page":"1219.e19","DOI":"10.1016\/j.amjmed.2017.05.023","article-title":"Intravenous immunoglobulins improve survival in monoclonal gammopathy-associated systemic capillary-leak syndrome","volume":"130","author":"Pineton de Chambrun","year":"2017","journal-title":"Am J Med"},{"key":"2025082622494933000_15.3.e248927.14","unstructured":"MHRA . 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