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A clonal B cell population was finally isolated by flow cytometry after multiple repeat marrow samples, and a diagnosis of splenic marginal zone lymphoma was subsequently reached. Response to single-agent rituximab was observed with resolution of splenomegaly, disappearance of the antibody and restoration of C1-INH levels.<\/jats:p>","DOI":"10.1136\/bcr-2022-249093","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T12:40:21Z","timestamp":1663591221000},"page":"e249093","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acquired angioedema: an unusual presentation of haematological malignancy"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-5157","authenticated-orcid":false,"given":"Daniel","family":"Farrugia","sequence":"first","affiliation":[{"name":"Haematology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Caruana Dingli","sequence":"additional","affiliation":[{"name":"Haematology, Mater Dei Hospital, Msida, 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