{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:12Z","timestamp":1756425732084,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,27]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Calcinosis cutis (CC) is the umbrella term for calcium salt deposition on skin and subcutaneous tissue. We present a unique case of CC associated with anti-Mi2-positive dermatomyositis, having a distinctive distribution of subcutaneous calcifications appearing as a \u2018lumbar belt\u2019. Treatment of CC remains challenging for clinicians due to a lack of high-quality evidence. Corticosteroids, methotrexate, bisphosphonates, intravenous immunoglobulin replacement, rituximab and sodium thiosulfate failed to halt calcinosis progression in this case. Newer therapies, such as Janus kinase inhibitors, should be considered.<\/jats:p>","DOI":"10.1136\/bcr-2022-249110","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:40:41Z","timestamp":1652874041000},"page":"e249110","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Therapy-resistant dermatomyositis with extensive \u2018lumbar belt\u2019 calcinosis"],"prefix":"10.1136","volume":"15","author":[{"given":"Juan Manuel","family":"Linan-Barroso","sequence":"first","affiliation":[{"name":"Dermatology, Hospital Universitario Virgen del Rocio, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-6130","authenticated-orcid":false,"given":"Alexei","family":"Gonzalez-Estrada","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-5483","authenticated-orcid":false,"given":"Jose Salvador","family":"Garc\u00eda-Morillo","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune and Rares Diseases Unit. Internal Medicine Department, Hospital Virgen del Rocio, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"2025082722233248000_15.5.e249110.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.006"},{"key":"2025082722233248000_15.5.e249110.2","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/bjd.15783","article-title":"Lack of response to intravenous sodium thiosulfate in three cases of extensive connective tissue disease-associated calcinosis cutis","volume":"178","author":"Song","year":"2018","journal-title":"Br J Dermatol"},{"key":"2025082722233248000_15.5.e249110.3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis","volume":"292","author":"Bohan","year":"1975","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025082722233248000_15.5.e249110.4","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.2052"},{"key":"2025082722233248000_15.5.e249110.5","first-page":"18","article-title":"Dermatomyosites Nouveaux anticorps, nouvelle classification","volume":"35","author":"Bolko","year":"2019","journal-title":"Med Sci"},{"key":"2025082722233248000_15.5.e249110.6","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.jaad.2020.03.058","article-title":"Systematic retrospective study of 64 patients with anti-Mi2 dermatomyositis: a classic skin rash with a necrotizing myositis and high risk of malignancy","volume":"83","author":"Monseau","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"2025082722233248000_15.5.e249110.7","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1093\/rheumatology\/keaa618","article-title":"Clinical features, treatments and outcomes of calcinosis in adult patients with dermatomyositis: a single cohort study","volume":"60","author":"Jiang","year":"2021","journal-title":"Rheumatology"},{"key":"2025082722233248000_15.5.e249110.8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jaut.2019.03.003","article-title":"Successful treatment of extensive calcifications and acute pulmonary involvement in dermatomyositis with the Janus-Kinase inhibitor tofacitinib - A report of two cases","volume":"100","author":"Wendel","year":"2019","journal-title":"J Autoimmun"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:23:42Z","timestamp":1756358622000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,18]]},"published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1136\/bcr-2022-249110"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249110","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}