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At 34\u2009weeks of gestation, the mother delivered a late preterm male neonate due to intrauterine growth restriction weighing 1590\u2009g with respiratory distress and cardiomyopathy at birth. The neonate had cerebral calcifications, hepatosplenomegaly and thrombocytopenia. As the infant\u2019s TORCH IgM titre was negative, pseudo-TORCH syndrome similar to AGS was suspected. Clinical exome sequencing of the parents and fetus identified no genes for hydrops fetalis or fetal cardiomyopathy; however, the AGS <jats:italic>TREX1<\/jats:italic> gene was identified in the neonate, while additional symptoms resembled TORCH infection. The neonate was discharged and has shown improvement with oral baricitinib treatment for the last 9 months.<\/jats:p>","DOI":"10.1136\/bcr-2022-249192","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:15:49Z","timestamp":1672312549000},"page":"e249192","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Aicardi-Gouti\u00e8res syndrome (AGS): recurrent fetal cardiomyopathy and pseudo-TORCH syndrome"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-0517","authenticated-orcid":false,"given":"Nalinikanta","family":"Panigrahy","sequence":"first","affiliation":[{"name":"Neonatology, Rainbow Children's Hospital Banjara Hills, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Bakhru","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Rainbow Children's Heart Institute, Hyderabad, Telengana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Lingappa","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Rainbow Children's Hospital Banjara Hills, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Chirla","sequence":"additional","affiliation":[{"name":"Intensive Care, Rainbow Children's Hospital, Hyderabad, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"2025082623253194000_15.12.e249192.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36887"},{"key":"2025082623253194000_15.12.e249192.2","unstructured":"Crow YJ . 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