{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:16:56Z","timestamp":1790921816235,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,3,29]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>A man in his 60s developed reactive arthritis following treatment with intravesical Bacillus Calmette-Guerin (iBCG) for papillary carcinoma of bladder. Evaluation revealed leucocytosis and raised inflammatory markers. HLA B27 was positive. Based on the temporal relationship, it was attributed to BCG-related reactive arthritis. iBCG was stopped. Treatment with non-steroidal anti-inflammatory drugs (NSAIDS) and glucocorticoids were ineffective. Prolonged course of disease-modifying antirheumatic drugs (DMARDS) was required which aided in alleviation of symptoms and sustained remission. Intravesical BCG therapy is a treatment for bladder cancer. It is rarely associated with reactive arthritis, which responds to discontinuation of iBCG and treatment with NSAIDS and\/or short-term glucocorticoids. iBCG-related reactive arthritis commonly has an acute\/subacute course. Chronic arthritis as observed in our case requiring prolonged treatment with DMARDS is rare.<\/jats:p>","DOI":"10.1136\/bcr-2022-249208","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:30:58Z","timestamp":1649856658000},"page":"e249208","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Reactive arthritis following treatment with intravesical Bacillus Calmette-Guerin for papillary carcinoma of bladder"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-0041","authenticated-orcid":false,"given":"Yogesh Preet","family":"Singh","sequence":"first","affiliation":[{"name":"Rheumatology, Manipal Hospital HAL Airport road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debaditya","family":"Roy","sequence":"additional","affiliation":[{"name":"Rheumatology, Manipal Hospital HAL Airport road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Jois","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Manipal Hospital HAL Airport road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Shetti","sequence":"additional","affiliation":[{"name":"Gastroenterology, Manipal Hospital HAL Airport road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"2025082802143969000_15.4.e249208.1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s10067-018-4022-5","article-title":"Reactive arthritis: update 2018","volume":"37","author":"Garc\u00eda-Kutzbach","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2025082802143969000_15.4.e249208.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.017"},{"key":"2025082802143969000_15.4.e249208.3","doi-asserted-by":"crossref","unstructured":"Ben Abdelghani K , Fazaa A , Souabni L . 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BMJ Case Rep 2014.","DOI":"10.1136\/bcr-2013-202741"},{"key":"2025082802143969000_15.4.e249208.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0059-2"},{"key":"2025082802143969000_15.4.e249208.5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jbspin.2016.09.014","article-title":"Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: a 20-year, two-centre retrospective study","volume":"84","author":"Taniguchi","year":"2017","journal-title":"Joint Bone Spine"},{"key":"2025082802143969000_15.4.e249208.6","article-title":"Reactive Arthritis - A Rare Complication of Intravesical BCG Instillation","volume":"7","author":"Freixa","year":"2020","journal-title":"Eur J Case Rep Intern Med"},{"key":"2025082802143969000_15.4.e249208.7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13691-018-0342-1","article-title":"Reiter's syndrome following intravesical Bacillus Calmette-Guerin therapy for bladder carcinoma: a report of five cases","volume":"7","author":"Nakagawa","year":"2018","journal-title":"Int Cancer Conf J"},{"key":"2025082802143969000_15.4.e249208.8","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-021-01004-y","article-title":"Reactive arthritis following Bacillus Calmette-Guerin therapy for bladder cancer: a systematic literature review","volume":"23","author":"Abdelghani","year":"2021","journal-title":"Curr Rheumatol Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:14:49Z","timestamp":1756372489000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,13]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bcr-2022-249208"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249208","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}