{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:10:07Z","timestamp":1756372207506,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,7,7]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Thrombotic complications during COVID-19 infections occur frequently, and anticoagulants to prevent and treat deep vein thrombosis appear to have a good safety profile in these patients. In addition, haemorrhagic complications during COVID-19 infections have also been reported. Hepatic inflammation can occur in COVID-19 infections as a direct consequence of cellular infection and cytopathy. Spontaneous subcapsular hepatic haematoma is extremely rare and can be life-threatening.<\/jats:p>\n               <jats:p>A woman in her 40s presented to the hospital with fever and shortness of breath and was diagnosed with COVID-19 infection with respiratory failure requiring intubation. On day 49 of hospitalisation, she developed melena and acute anaemia; her haemoglobin dropped from 97g\/L (9.7g\/dL) to 56g\/L (5.6g\/dL). Abdominal and pelvic CT scans showed a large subcapsular liver haematoma with retroperitoneal extension. The patient received blood transfusions and remained haemodynamically stable. She was eventually extubated and discharged home.<\/jats:p>","DOI":"10.1136\/bcr-2022-249256","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T11:45:10Z","timestamp":1658749510000},"page":"e249256","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous large liver haematoma with extensive intraperitoneal bleeding in a patient with COVID-19 infection"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-4272","authenticated-orcid":false,"given":"Busara","family":"Songtanin","sequence":"first","affiliation":[{"name":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbie","family":"Evans","sequence":"additional","affiliation":[{"name":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Nugent","sequence":"additional","affiliation":[{"name":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"2025082801382962000_15.7.e249256.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.002"},{"key":"2025082801382962000_15.7.e249256.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208626"},{"key":"2025082801382962000_15.7.e249256.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006520"},{"key":"2025082801382962000_15.7.e249256.4","doi-asserted-by":"crossref","DOI":"10.11604\/pamj.2021.38.142.28172","article-title":"A giant spontaneous subcapsular hematoma of the liver revealing a COVID-19 infection, a coincidence? (a case report)","volume":"38","author":"Tidjane","year":"2021","journal-title":"Pan Afr Med J"},{"key":"2025082801382962000_15.7.e249256.5","article-title":"Spontaneous intraparenchymal hepatic hemorrhage as a sequela of COVID-19","volume":"12","author":"Daid","year":"2020","journal-title":"Cureus"},{"key":"2025082801382962000_15.7.e249256.6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/hpb.12474","article-title":"Spontaneous hepatic haemorrhage: a review of pathogenesis, aetiology and treatment","volume":"17","author":"Srinivasa","year":"2015","journal-title":"HPB"},{"key":"2025082801382962000_15.7.e249256.7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2020.06.017","article-title":"Cytokine Storms: understanding COVID-19","volume":"53","author":"Mangalmurti","year":"2020","journal-title":"Immunity"},{"key":"2025082801382962000_15.7.e249256.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.24.2994"},{"key":"2025082801382962000_15.7.e249256.9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.8.790"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:38:38Z","timestamp":1756370318000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,25]]},"published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1136\/bcr-2022-249256"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249256","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}