{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:16:51Z","timestamp":1780539411895,"version":"3.54.1"},"reference-count":38,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,3,19]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer which most commonly occurs on the head and neck. A limited number of cases of MCC of the hand have been reported in the English literature. We describe a case of MCC of the hand in a man in his late 60s. The lesion presented on the dorsum of the left fifth digit, with metastasis to the left axillary lymph nodes. The primary lesion grew rapidly over a span of 3\u2009months. The patient was treated with two courses of neoadjuvant nivolumab, amputation of the digit and left axillary lymph node resection followed by radiotherapy to the left hand and left axilla. He continues to follow-up for radiotherapy treatment 3\u2009months postoperatively.<\/jats:p>","DOI":"10.1136\/bcr-2022-249288","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T12:54:33Z","timestamp":1648644873000},"page":"e249288","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Unique presentation of Merkel cell tumour affecting the hand"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6982-7856","authenticated-orcid":false,"given":"Julia","family":"Tomtschik","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sweitzer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic Surgery, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic Surgery, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2025082800545287000_15.3.e249288.1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620040075020"},{"key":"2025082800545287000_15.3.e249288.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172890"},{"key":"2025082800545287000_15.3.e249288.3","doi-asserted-by":"crossref","first-page":"17077","DOI":"10.1038\/nrdp.2017.77","article-title":"Merkel cell carcinoma","volume":"3","author":"Becker","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2025082800545287000_15.3.e249288.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2010.02.002"},{"key":"2025082800545287000_15.3.e249288.5","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050044"},{"key":"2025082800545287000_15.3.e249288.6","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0616"},{"key":"2025082800545287000_15.3.e249288.7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.hoc.2018.08.002","article-title":"Merkel cell carcinoma review","volume":"33","author":"Xue","year":"2019","journal-title":"Hematol Oncol Clin North Am"},{"key":"2025082800545287000_15.3.e249288.8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.det.2019.06.002","article-title":"Updates on Merkel cell carcinoma","volume":"37","author":"Emge","year":"2019","journal-title":"Dermatol Clin"},{"key":"2025082800545287000_15.3.e249288.9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1017\/S0022215116000153","article-title":"Merkel cell carcinoma of the head and neck: poorer prognosis than non-head and neck sites","volume":"130","author":"Morand","year":"2016","journal-title":"J Laryngol Otol"},{"key":"2025082800545287000_15.3.e249288.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.11.020"},{"key":"2025082800545287000_15.3.e249288.11","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"2025082800545287000_15.3.e249288.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"2025082800545287000_15.3.e249288.13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0702"},{"key":"2025082800545287000_15.3.e249288.14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.virol.2017.03.007","article-title":"Isolation and characterization of a novel putative human polyomavirus","volume":"506","author":"Gheit","year":"2017","journal-title":"Virology"},{"key":"2025082800545287000_15.3.e249288.15","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02079-16"},{"key":"2025082800545287000_15.3.e249288.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.06.004"},{"key":"2025082800545287000_15.3.e249288.17","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00438-12"},{"key":"2025082800545287000_15.3.e249288.18","first-page":"205846011770044","article-title":"Frequency and locations of systemic metastases in Merkel cell carcinoma by imaging","volume":"6","author":"Kouzmina","year":"2017","journal-title":"Acta Radiol Open"},{"key":"2025082800545287000_15.3.e249288.19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejca.2016.10.022","article-title":"Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs","volume":"71","author":"Schadendorf","year":"2017","journal-title":"Eur J Cancer"},{"key":"2025082800545287000_15.3.e249288.20","unstructured":"Brady M , Spiker AM . 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