{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:51:38Z","timestamp":1786632698010,"version":"build-2736575974"},"reference-count":38,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,18]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Malaria remains one of the most prevalent infectious diseases globally. Despite targets set out by the WHO in 2015, there has been a rise in the number of cases since 2019 as an indirect effect of the COVID-19 pandemic.<\/jats:p><jats:p>Cardiac complications are very rarely witnessed with severe malaria. Of the cardiac sequelae, myocarditis is one of the most frequently observed with a handful of case reports in the literature. We report a case of a man in his 50s who developed myocarditis while being managed for severe<jats:italic>Plasmodium falciparum<\/jats:italic>malaria in an intensive care unit in the UK and review the literature relevant to this case. This is the second reported case of this condition in the UK.<\/jats:p>","DOI":"10.1136\/bcr-2022-249363","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T17:44:57Z","timestamp":1669311897000},"page":"e249363","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Case of myocarditis secondary to severe<i>Plasmodium falciparum<\/i>infection"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3335-9346","authenticated-orcid":false,"given":"Angharad","family":"Langdon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-5459","authenticated-orcid":false,"given":"Ihab","family":"Abdlaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-3721","authenticated-orcid":false,"given":"Kim","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3335-9346","authenticated-orcid":false,"given":"Jayson","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"2024051412411970000_15.11.e249363.1","unstructured":"World health organisation: 2021 malaria report. Available: https:\/\/www.who.int\/teams\/global-malariaprogramme\/reports\/world-malaria-report-2021 [Accessed 6 Jan 2022]."},{"key":"2024051412411970000_15.11.e249363.2","unstructured":"World health organisation: COVID-19 Dashboard. Available: https:\/\/covid19.who.int\/ [Accessed 7 Jan 2022]."},{"key":"2024051412411970000_15.11.e249363.3","unstructured":"Public Health England . Malaria imported into the United Kingdom: 2019. Available: https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/989677\/Malaria_imported_into_the_United_Kingdom_in_2019.pdf [Accessed 6 Jan 2022]."},{"key":"2024051412411970000_15.11.e249363.4","first-page":"7","article-title":"Severe malaria","volume":"19 Suppl 1","year":"2014","journal-title":"Trop Med Int Health"},{"key":"2024051412411970000_15.11.e249363.5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2310\/7060.2001.22133","article-title":"Myocarditis associated with Plasmodium falciparum malaria: a case report and a review of the literature","volume":"8","author":"Mohsen","year":"2001","journal-title":"J Travel Med"},{"key":"2024051412411970000_15.11.e249363.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/487250","article-title":"Malariometric survey of ibeshe community in ikorodu, Lagos state: dry season","volume":"2013","author":"Aina","year":"2013","journal-title":"Malar Res Treat"},{"key":"2024051412411970000_15.11.e249363.7","first-page":"413","article-title":"Complicated Plasmodium falciparum malaria initially presenting as myocardites","volume":"26","author":"Khattak","year":"2014","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"2024051412411970000_15.11.e249363.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/202083","article-title":"Fatal myocarditis in course of Plasmodium falciparum infection: case report and review of cardiac complications in malaria","volume":"2011","author":"Costenaro","year":"2011","journal-title":"Case Rep Med"},{"key":"2024051412411970000_15.11.e249363.9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s15010-002-3143-5","article-title":"Fatal malaria in a German couple returning from Burkina Faso","volume":"31","author":"Wichmann","year":"2003","journal-title":"Infection"},{"key":"2024051412411970000_15.11.e249363.10","unstructured":"Kenneth NK , Pang LY , Nam LH . The use of ECMO in treating a patient with shock due to Plasmodium falciparum malaria and myocarditis, 2015. Available: https:\/\/api.semanticscholar.org\/CorpusID:32972124 [Accessed 6 Jan 2022]."},{"key":"2024051412411970000_15.11.e249363.11","first-page":"53","article-title":"Myocarditis in Course of P. Falciparum and P. Vivax Infection: Case Report and Review of Cardiac Complications in Malaria","volume":"6","author":"Patel","year":"2013","journal-title":"IOSR Journal of Dental and Medical Services"},{"key":"2024051412411970000_15.11.e249363.12","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmp050"},{"key":"2024051412411970000_15.11.e249363.13","first-page":"413","article-title":"Varied presentation of complicated falciparum malaria in a family","volume":"49","author":"Sanklecha","year":"2012","journal-title":"Indian Pediatr"},{"key":"2024051412411970000_15.11.e249363.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8305.2008.00292.x"},{"key":"2024051412411970000_15.11.e249363.15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/jfcm.JFCM_78_19","article-title":"Imported Plasmodium vivax malaria complicated by reversible myocarditis","volume":"26","author":"Khan","year":"2019","journal-title":"J Family Community Med"},{"key":"2024051412411970000_15.11.e249363.16","first-page":"S96","article-title":"Myocarditis complicating Plasmodium vivax malaria","volume":"24 Suppl 2","author":"Nasir","year":"2014","journal-title":"J Coll Physicians Surg Pak"},{"key":"2024051412411970000_15.11.e249363.17","first-page":"45","article-title":"Plasmodium vivax myocarditis in a child","volume":"1","author":"Mustafa","year":"2011","journal-title":"Int Multidiscip Res J"},{"key":"2024051412411970000_15.11.e249363.18","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1590\/0037-8682-0126-2014","article-title":"Myocarditis associated with Plasmodium vivax malaria: a case report","volume":"47","author":"Ventura","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"key":"2024051412411970000_15.11.e249363.19","first-page":"944","article-title":"Vivax malaria complicated by myocarditis","volume":"61","author":"Gantait","year":"2013","journal-title":"J Assoc Physicians India"},{"key":"2024051412411970000_15.11.e249363.20","article-title":"Plasmodium vivax induced myocarditis: a rare case report","volume":"31","author":"Gupta","year":"2013","journal-title":"Indian J Med Microbiol"},{"key":"2024051412411970000_15.11.e249363.21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1590\/0037-8682-0087-2014","article-title":"An unusual case of heart failure due to Plasmodium vivax infection with a favorable outcome","volume":"47","author":"Dev","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"key":"2024051412411970000_15.11.e249363.22","doi-asserted-by":"crossref","unstructured":"Sonambekar A , Gupta N , Agarwal M , et al . Plasmodium Vivax Associated Myocarditis. Eur J Case Rep Intern Med 2014;1.doi:10.12890\/2014_000039","DOI":"10.12890\/2014_000039"},{"key":"2024051412411970000_15.11.e249363.23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5152\/etd.2018.18085","article-title":"Plasmodium vivax malaria causing cardiomyopathy and thrombotic microangiopathy: a rare association","volume":"40","author":"Jain","year":"2018","journal-title":"Erciyes Med J"},{"key":"2024051412411970000_15.11.e249363.24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2165-7920.1000945","article-title":"Malarial myocarditis: a rare complication of Plasmodium vivax: case report","volume":"07","author":"Kumar","year":"2017","journal-title":"J Clin Case Rep"},{"key":"2024051412411970000_15.11.e249363.25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/INJMS.INJMS_6_18","article-title":"Myocarditis with sinus exit block: A rare presentation of Plasmodium vivax malaria","volume":"10","author":"Arora","year":"2019","journal-title":"Indian Journal of Medical Specialities"},{"key":"2024051412411970000_15.11.e249363.26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/mamcjms.mamcjms_4_19","article-title":"Severe Complicated Plasmodium vivax Malaria: A Case Report","volume":"5","author":"Kumar","year":"2019","journal-title":"MAMC Journal of Medical Sciences"},{"key":"2024051412411970000_15.11.e249363.27","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jacc.2020.12.042","article-title":"Malaria and the heart: JACC state-of-the-art review","volume":"77","author":"Gupta","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2024051412411970000_15.11.e249363.28","first-page":"385","article-title":"Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration","volume":"119","author":"MacPherson","year":"1985","journal-title":"Am J Pathol"},{"key":"2024051412411970000_15.11.e249363.29","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90240-X"},{"key":"2024051412411970000_15.11.e249363.30","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.4269\/ajtmh.20-1414","article-title":"Prevalence of cardiovascular complications in malaria: a systematic review and meta-analysis","volume":"104","author":"Holm","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"2024051412411970000_15.11.e249363.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01635.x"},{"key":"2024051412411970000_15.11.e249363.32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1923.02650060042012"},{"key":"2024051412411970000_15.11.e249363.33","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70187-1"},{"key":"2024051412411970000_15.11.e249363.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90126-3"},{"key":"2024051412411970000_15.11.e249363.35","doi-asserted-by":"crossref","first-page":"964","DOI":"10.4269\/ajtmh.1999.61.964","article-title":"No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine","volume":"61","author":"van Vugt","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"2024051412411970000_15.11.e249363.36","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-1"},{"key":"2024051412411970000_15.11.e249363.37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-3156.2003.00978.x","article-title":"Myocardial damage in falciparum malaria detectable by cardiac troponin T is rare","volume":"8","author":"G\u00fcnther","year":"2003","journal-title":"Trop Med Int Health"},{"key":"2024051412411970000_15.11.e249363.38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01303.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T20:03:28Z","timestamp":1715717008000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,24]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-249363"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249363","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}