{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:23Z","timestamp":1756339463710,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,6,10]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Chronic lymphoedema can rarely be complicated by an angiosarcoma. This combination called Stewart-Treves syndrome usually observed in upper limb in patients of post-mastectomy with axillary lymph node resection. Here, we report a male patient who had a 10-year history of right leg elephantiasis. Later on, he developed two large ulceronodular masses in the same leg with few satellite nodules in the surrounding skin. With the clinical suspicion of malignancy, a wedge biopsy was performed which revealed histological features of angiosarcoma with sickled red cells. The above knee amputation specimen received further confirmed the histological diagnosis. The investigation for haemoglobinopathy also suggested the presence of sickle cell trait. This report describes a multifocal tumour as a rare manifestation of Stewart-Treves syndrome in a post-filariasis case with sickle cell trait, which is an extremely uncommon combination.<\/jats:p>","DOI":"10.1136\/bcr-2022-249379","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:00:45Z","timestamp":1657108845000},"page":"e249379","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Unusual coexistence of Stewart-Treves syndrome and sickle cell anaemia: a case of dual pathology"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1717-6649","authenticated-orcid":false,"given":"Vaishali A","family":"Walke","sequence":"first","affiliation":[{"name":"Pathology & Lab Medicine, All India Institute of Medical Science-Bhopal, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Datar","sequence":"additional","affiliation":[{"name":"Pathology, IGGMCH, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwant","family":"Kowe","sequence":"additional","affiliation":[{"name":"Pathology, IGGMCH, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-4717","authenticated-orcid":false,"given":"Jai Kumar","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Pathology & Lab Medicine, All India Institute of Medical Science-Bhopal, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"2025082707251766000_15.7.e249379.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W"},{"key":"2025082707251766000_15.7.e249379.2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318176dbc7"},{"key":"2025082707251766000_15.7.e249379.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197208)30:2<562::AID-CNCR2820300237>3.0.CO;2-V"},{"key":"2025082707251766000_15.7.e249379.4","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120909"},{"key":"2025082707251766000_15.7.e249379.5","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1979.01370250084018"},{"key":"2025082707251766000_15.7.e249379.6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000445427","article-title":"Stewart-Treves syndrome: a case report and review of the literature","volume":"9","author":"Berebichez-Fridman","year":"2016","journal-title":"Case Rep Oncol"},{"key":"2025082707251766000_15.7.e249379.7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.clindermatol.2014.04.008","article-title":"Lymphedema-related angiogenic tumors and other malignancies","volume":"32","author":"Lee","year":"2014","journal-title":"Clin Dermatol"},{"key":"2025082707251766000_15.7.e249379.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.07.027"},{"key":"2025082707251766000_15.7.e249379.9","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/iwj.13185","article-title":"A case of Stewart-Treves syndrome of the lower limbs: the usefulness of dermoscopy","volume":"16","author":"Marasca","year":"2019","journal-title":"Int Wound J"},{"key":"2025082707251766000_15.7.e249379.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.0406"},{"key":"2025082707251766000_15.7.e249379.11","doi-asserted-by":"crossref","unstructured":"Orell SR , Domanski H . Orell and Sterrett\u2019s Fine needle Aspiration Cytology. In: Houston M , Nash: S , eds. Churchill Livingston. 5th edition. India: Elsevier, 2012: 370\u201386.","DOI":"10.1016\/B978-0-7020-3151-9.00014-1"},{"key":"2025082707251766000_15.7.e249379.12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5999\/aps.2013.40.3.275","article-title":"Clinical experience of stewart-treves syndrome in the lower leg","volume":"40","author":"Lee","year":"2013","journal-title":"Arch Plast Surg"},{"key":"2025082707251766000_15.7.e249379.13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0000000000000029","article-title":"Sickle cell disease in India","volume":"21","author":"Colah","year":"2014","journal-title":"Curr Opin Hematol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:25:24Z","timestamp":1756304724000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,6]]},"published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1136\/bcr-2022-249379"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249379","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}