{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:50:48Z","timestamp":1787169048557,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,12,10]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Hemimegalencephaly (HME) is a rare neurological diagnosis defined as hamartomatous overgrowth of one cerebral hemisphere. The hypothesised pathogenesis is due to an increased number or size of neural cells; however, the exact mechanism can vary widely, depending on the underlying aetiology. We report a case outlining the prenatal diagnostic process and obstetric considerations for delivering an infant with HME secondary to megalencephaly\u2013capillary malformation syndrome. After diagnosis, our patient was induced and delivered at 37 weeks of gestation via operative vaginal delivery. To our knowledge, this is the first report describing the course from prenatal diagnosis through delivery of a fetus with HME.<\/jats:p>","DOI":"10.1136\/bcr-2022-249587","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T10:30:13Z","timestamp":1672050613000},"page":"e249587","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal diagnosis and delivery of megalencephaly\u2013capillary malformation syndrome"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-1381","authenticated-orcid":false,"given":"Mokshal","family":"Porwal","sequence":"first","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyon","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrahim Nagayoshi","family":"Razzak","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"2025082800383062000_15.12.e249587.1","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/j.crad.2014.01.026","article-title":"The diagnosis of hemimegalencephaly using in utero MRI","volume":"69","author":"Williams","year":"2014","journal-title":"Clin Radiol"},{"key":"2025082800383062000_15.12.e249587.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31401"},{"key":"2025082800383062000_15.12.e249587.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0149-9"},{"key":"2025082800383062000_15.12.e249587.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.inhe.2011.12.006"},{"key":"2025082800383062000_15.12.e249587.5","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199606000-00022"},{"key":"2025082800383062000_15.12.e249587.6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1600-0412.2012.01358.x","article-title":"The influence of fetal head circumference on labor outcome: a population\u2010based register study","volume":"91","author":"Elvander","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2025082800383062000_15.12.e249587.7","doi-asserted-by":"crossref","first-page":"265.e1","DOI":"10.1016\/j.ajog.2014.03.021","article-title":"Neonatal outcomes in early term birth","volume":"211","author":"Parikh","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2025082800383062000_15.12.e249587.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2017.01.003"},{"key":"2025082800383062000_15.12.e249587.9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3171\/2020.1.PEDS19537","article-title":"Long-Term outcomes after surgery for catastrophic epilepsy in infants: institutional experience and review of the literature","volume":"26","author":"Ye","year":"2020","journal-title":"J Neurosurg Pediatr"},{"key":"2025082800383062000_15.12.e249587.10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00381-016-3289-6","article-title":"\u201cEndovascular embolic hemispherectomy\u201d: a strategy for the initial management of catastrophic holohemispheric epilepsy in the neonate","volume":"33","author":"Oluigbo","year":"2017","journal-title":"Child's Nervous System"},{"key":"2025082800383062000_15.12.e249587.11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.8.720"},{"key":"2025082800383062000_15.12.e249587.12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/0883073818813238","article-title":"mTOR inhibitors as a new therapeutic strategy in treatment resistant epilepsy in hemimegalencephaly: a case report","volume":"34","author":"Xu","year":"2019","journal-title":"J Child Neurol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:38:41Z","timestamp":1756366721000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,26]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bcr-2022-249587"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249587","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}