{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:21:27Z","timestamp":1758478887082,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,7,22]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Nephropathic apolipoprotein L1 (APOL1) risk alleles (G1\/G2) have been associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, Systemic lupus erythematosus (SLE)-associated collapsing glomerulopathy and other glomerulonephritides. These alleles confer protection from <jats:italic>Trypanosoma brucei<\/jats:italic> infections which are enriched in sub-Saharan African populations. We present a young woman with obesity, hypertension, subnephrotic range proteinuria who was found to have obesity-related glomerulopathy on kidney biopsy while harbouring two high-risk APOL1 alleles (G1\/G2). Given the potential effects on lipid metabolism and their association with obesity, the presence of APOL1 risk alleles may impact cardiovascular health in addition to renal disease in these patients.<\/jats:p>","DOI":"10.1136\/bcr-2022-249624","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T11:15:47Z","timestamp":1660907747000},"page":"e249624","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Obesity-related glomerulopathy in the presence of APOL1 risk alleles"],"prefix":"10.1136","volume":"15","author":[{"given":"Ronald","family":"Valdez Imbert","sequence":"first","affiliation":[{"name":"Department of Medicine, Jacobi Medical Center at Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nang San","family":"Hti Lar Seng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobi Medical 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