{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:21Z","timestamp":1756339341394,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,6,7]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>A man in his 70s presents with 12 months of progressive dyspnoea, sicca symptoms and Raynaud\u2019s phenomenon. Serological testing and tear duct biopsy confirm Sj\u00f6gren\u2019s syndrome (SS). Bilateral nodular-cystic appearances highly suggestive of lymphoid interstitial pneumonia (LIP) are noted on high-resolution computed tomography (HRCT), supported by a 40% lymphocytosis on bronchoalveolar lavage.<\/jats:p>\n               <jats:p>Biopsy of a non-characteristic additional pulmonary nodule diagnoses light chain deposition disease (LCDD). Extrapulmonary organ involvement is excluded. Pulmonary function tests are well-preserved, and the patient is kept under active surveillance without requiring immunomodulatory treatment.<\/jats:p>\n               <jats:p>LIP and LCDD both have a strong association with SS. Identification of these disease associations is crucial as they may result in multiorgan involvement or progression to haematological malignancy. This is the first case published in the literature and highlights that a pragmatic approach to investigations can avoid unnecessary procedures, and that treatment may be guided by symptomology.<\/jats:p>","DOI":"10.1136\/bcr-2022-249747","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:45:22Z","timestamp":1656067522000},"page":"e249747","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Sj\u00f6gren\u2019s syndrome as a cause of both lymphoid interstitial pneumonia and light chain deposition disease in a single patient"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-4665","authenticated-orcid":false,"given":"Matthew","family":"Steward","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK"},{"name":"College of Medicine and Health, University of Exeter Medical School, Exeter, Devon, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-3955","authenticated-orcid":false,"given":"Johannes H","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Medicine and Health, University of Exeter Medical School, Exeter, Devon, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"2025082622542548000_15.6.e249747.1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq240"},{"key":"2025082622542548000_15.6.e249747.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00076705"},{"key":"2025082622542548000_15.6.e249747.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-658872"},{"key":"2025082622542548000_15.6.e249747.4","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.2.r99au05567"},{"key":"2025082622542548000_15.6.e249747.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.6.2150"},{"key":"2025082622542548000_15.6.e249747.6","first-page":"128","article-title":"Lymphoid interstitial pneumonia: findings at bronchoalveolar lavage","volume":"67","author":"Ishizaki","year":"1985","journal-title":"Eur J Respir Dis"},{"key":"2025082622542548000_15.6.e249747.7","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-019-02147-4","article-title":"The pathogenesis of renal injury and treatment in light chain deposition disease","volume":"17","author":"Wang","year":"2019","journal-title":"J Transl Med"},{"key":"2025082622542548000_15.6.e249747.8","doi-asserted-by":"publisher","DOI":"10.4065\/77.2.193"},{"key":"2025082622542548000_15.6.e249747.9","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.1.88"},{"key":"2025082622542548000_15.6.e249747.10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13548"},{"key":"2025082622542548000_15.6.e249747.11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-872028"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:54:32Z","timestamp":1756274072000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,24]]},"published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1136\/bcr-2022-249747"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249747","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}