{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:15:11Z","timestamp":1783336511093,"version":"3.54.6"},"reference-count":19,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,5,8]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>A woman in her 50s developed meningitis following an endoscopic, endonasal resection of a clival meningioma which was complicated by a cerebrospinal fluid (CSF) leak through the nose. CSF analysis showed a raised white cell count, and <jats:italic>Capnocytophaga sputigena<\/jats:italic> was isolated. This organism is an oral commensal and is implicated in periodontal disease; the CSF leak explains the portal of entry. <jats:italic>C. sputigena<\/jats:italic> is rarely isolated, and this is the first report of a central nervous system (CNS) infection caused by this organism. A worsening of our patient\u2019s dermatological condition, urticaria pigmentosa, coincided with empiric treatment with vancomycin and meropenem, which were therefore discontinued. Treatment was continued with chloramphenicol for 3\u2009weeks, and the patient made a full recovery. Systemic chloramphenicol is uncommonly used in contemporary UK practice, but remains an excellent antibiotic for CNS penetration and it has excellent bioavailability. We anticipate increased chloramphenicol use as the number of multiresistant Gram-negative infection increases.<\/jats:p>","DOI":"10.1136\/bcr-2022-249821","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T11:55:32Z","timestamp":1653479732000},"page":"e249821","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of <i>Capnocytophaga sputigena<\/i> meningitis in a neurosurgical patient"],"prefix":"10.1136","volume":"15","author":[{"given":"Terry John","family":"Evans","sequence":"first","affiliation":[{"name":"Infection Care Group, St George's University Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samitha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Infection Care Group, St George's University Hospitals NHS Foundation Trust, London, 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