{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:53:32Z","timestamp":1790726012846,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,5]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Hyperandrogenism with virilisation de novo in postmenopausal women is exceedingly rare, with aetiology oscillating between ovarian tumours, adrenal tumours, ovarian hyperthecosis and, less frequently, Cushing\u2019s syndrome. We report a case of a postmenopausal woman in her late 60s, referred from her primary healthcare physician to a gynaecology appointment due to hirsutism and vasomotor symptoms. At physical examination, clitoromegaly was also identified. Blood tests revealed severe hyperandrogenemia, with total testosterone above 200\u2009ng\/dL, but transvaginal ultrasound and abdominal CT were unremarkable. Three months later, abdominal CT was repeated, revealing a moderate heterogeneous enhancement with 18\u2009mm on the left ovary, which was confirmed by transvaginal ultrasound. Total laparoscopic hysterectomy with bilateral adnexectomy was performed. Histopathological examination reported an ovarian steroid cell tumour not otherwise specified on the left ovary and bilateral ovarian hyperthecosis. Two months later, the patient had normal total testosterone and the hirsutism complaints were completely absent.<\/jats:p>","DOI":"10.1136\/bcr-2022-249907","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:20:30Z","timestamp":1653304830000},"page":"e249907","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Ovarian steroid cell tumour inducing virilisation in a postmenopausal woman"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-4249","authenticated-orcid":false,"given":"Ana Marta","family":"Pinto","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Boia","family":"Martins","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"2025082709280800000_15.4.e249907.1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(02)02985-0","article-title":"Androgen production in women","volume":"77(Suppl 4)","author":"Burger","year":"2002","journal-title":"Fertil Steril"},{"key":"2025082709280800000_15.4.e249907.2","first-page":"624","article-title":"Changes in circulating steroids with aging in postmenopausal 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