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We describe a case of symptomatic leptomeningeal leukaemic involvement as an atypical presentation of CLL relapse. A favourable clinical response was observed following systemic monotherapy with venetoclax.<\/jats:p>","DOI":"10.1136\/bcr-2022-249940","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T11:05:30Z","timestamp":1654686330000},"page":"e249940","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Symptomatic leptomeningeal carcinomatosis: a rare presentation of chronic lymphocytic leukaemia relapse"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-2441","authenticated-orcid":false,"given":"Osama","family":"Batayneh","sequence":"first","affiliation":[{"name":"Department of Medicine, Kent Hospital\/ The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Lin","sequence":"additional","affiliation":[{"name":"OMS-III, University of New England College of 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