{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:17:59Z","timestamp":1787239079291,"version":"build-2736575974"},"reference-count":25,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,8,23]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Improving maternal and child health is a global priority. Although infection with\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    (LM), a small facultative anaerobic, gram-positive motile bacillus is rare, when it infects the maternal-fetoplacental unit, it can result in adverse fetal sequelae such as chorioamnionitis, preterm labour, neonatal sepsis, meningitis and neonatal death. Pregnancy-associated listeriosis may present with a plethora of diverse, non-specific symptoms such as fever, influenza-like or gastrointestinal symptoms, premature contractions and preterm labour. It has a predilection for the second and third trimester of pregnancy, occurring sporadically or as part of an outbreak, most of which have involved unpasteurised dairy products, long shelf life products, contaminated ready-to-eat food, deli meats and soft cheeses. Strains belonging to the clonal complexes 1, 4 and 6 are hypervigilant and are commonly associated with maternal-neonatal infections. Maternal listeriosis occurs as a direct consequence of LM-specific placental tropism, which is mediated by the conjugated action of internalin A and internalin B at the placental barrier. The diagnosis is established from placental culture. Penicillin, ampicillin and amoxicillin are the antimicrobials of choice. It has a high fetal morbidity of up to 30%. The authors present the case of a multiparous woman in her early 20s presenting with sepsis and preterm premature rupture of her membranes at 21 weeks gestation. A live baby was delivered spontaneously and died shortly after birth. Placental cultures and postmortem examination were consistent with the diagnosis of disseminated\n                    <jats:italic>Listeria<\/jats:italic>\n                    infection. Due to the increased susceptibility of pregnant women for LM, a high index of clinical suspicion is required to establish the diagnosis and initiate appropriate antimicrobial therapy to reduce adverse fetal outcomes.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2022-249989","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T10:30:17Z","timestamp":1664793017000},"page":"e249989","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal sepsis caused by\n                    <i>Listeria monocytogenes<\/i>\n                    with a fatal fetal outcome"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-415X","authenticated-orcid":false,"given":"Louise","family":"Dunphy","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Leighton Hospital, Crewe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamatha","family":"Polkampali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leighton Hospital, Crewe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Pathology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leighton Hospital, Crewe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2025082710570504000_15.10.e249989.1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/br.30.2.309-382.1966","article-title":"Listeria monocytogenes and listeric infections","volume":"30","author":"Gray","year":"1966","journal-title":"Bacteriol Rev"},{"key":"2025082710570504000_15.10.e249989.2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700290409"},{"key":"2025082710570504000_15.10.e249989.3","first-page":"265","article-title":"Lefvernekos HOS kaninorsakad a fen EJ forut beskrifven bakteria","volume":"2","author":"Hulphers","year":"1911","journal-title":"Svenska Vet Tidskr"},{"key":"2025082710570504000_15.10.e249989.4","first-page":"163","article-title":"A new disease of wild rodents, \u2018tiger river disease\u2019","volume":"3","author":"Pirie","year":"1927","journal-title":"Publications of the South African Institute for Medical Research"},{"key":"2025082710570504000_15.10.e249989.5","first-page":"590","article-title":"Etiologie de la mononucleose infectieuse","volume":"101","author":"Nyfeldt","year":"1929","journal-title":"Compt rend Soc Biol"},{"key":"2025082710570504000_15.10.e249989.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420090077035"},{"key":"2025082710570504000_15.10.e249989.7","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200205009"},{"key":"2025082710570504000_15.10.e249989.8","first-page":"413","article-title":"Listeria monocytogenes: a foodborne pathogen","volume":"138","author":"Farber","year":"1988","journal-title":"CMAJ"},{"key":"2025082710570504000_15.10.e249989.9","first-page":"210","article-title":"Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia","volume":"25","author":"Pagliano","year":"2017","journal-title":"Infez Med"},{"key":"2025082710570504000_15.10.e249989.10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/cid\/cis268","article-title":"Invasive listeriosis in the foodborne diseases active surveillance network. food net. 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