{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:53:30Z","timestamp":1780646010512,"version":"3.54.1"},"reference-count":13,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"unspecified","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,8,7]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>A man in his 50s presented to the eye emergency department on three separate occasions complaining of blurred vision and discomfort in the left eye. He had a history of Marfan syndrome and had undergone bilateral 20-gauge (G) pars plana vitrectomy and lensectomy 20 years prior for ectopia lentis. On examination he had epithelial corneal oedema, raised intraocular pressure &gt;40\u2009mm Hg and conjunctival chemosis, which later appeared as a bleb-like conjunctival elevation. Acute treatment with oral acetazolamide and topical ocular hypotensive agents produced a marked reduction in intraocular pressure to 2\u20134\u2009mm Hg. A presumed diagnosis of a leaking scleral wound was made. He underwent scleral exploration under general anaesthesia and a leaking sclerotomy was uncovered. The defect was repaired successfully using a scleral patch graft. Late dehiscence of a sclerotomy has been reported rarely in patients with Marfan syndrome. This is the first reported case to present atypically with intermittent episodes of raised intraocular pressure rather than with hypotony.<\/jats:p>","DOI":"10.1136\/bcr-2022-249990","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T11:35:32Z","timestamp":1661859332000},"page":"e249990","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Late onset sclerotomy dehiscence in a patient with Marfan syndrome presenting as recurrent episodes of raised intraocular pressure"],"prefix":"10.1136","volume":"15","author":[{"given":"Paul Eduard","family":"Stanciu","sequence":"first","affiliation":[{"name":"Ophthalmology department, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"O'Regan","sequence":"additional","affiliation":[{"name":"Ophthalmology department, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edel","family":"Cosgrave","sequence":"additional","affiliation":[{"name":"Ophthalmology department, University Hospital Waterford, Waterford, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"2025082711210772000_15.8.e249990.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201851"},{"key":"2025082711210772000_15.8.e249990.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.11.1312"},{"key":"2025082711210772000_15.8.e249990.3","unstructured":"Nemet AY , Assia EI , Apple DJ . Major review current concepts of ocular manifestations in Marfan syndrome."},{"key":"2025082711210772000_15.8.e249990.4","doi-asserted-by":"crossref","unstructured":"Turaga K , Senthil S , Jalali S . Recurrent spontaneous scleral rupture in Marfan\u2019s syndrome. BMJ Case Rep 2016:bcr2016214764.doi:10.1136\/bcr-2016-214764","DOI":"10.1136\/bcr-2016-214764"},{"key":"2025082711210772000_15.8.e249990.5","first-page":"167","article-title":"Spontaneous scleral perforation and optic nerve dural ectasia in Marfan syndrome","volume":"25","author":"Sharifipour","year":"2013","journal-title":"Iran J Ophthalmol"},{"key":"2025082711210772000_15.8.e249990.6","unstructured":"Fan F , Luo Y , Liu X . Risk factors for postoperative complications in lensectomy-vitrectomy with or without intraocular lens placement in ectopia lentis associated with Marfan syndrome. Br J Ophthalmol 2008."},{"key":"2025082711210772000_15.8.e249990.7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0974-620X.169893","article-title":"Delayed sclerotomy wound dehiscence after lensectomy and vitrectomy in Marfan syndrome","volume":"8","author":"Sridhar","year":"2015","journal-title":"Oman J Ophthalmol"},{"key":"2025082711210772000_15.8.e249990.8","doi-asserted-by":"crossref","first-page":"830","DOI":"10.5301\/ejo.5000124","article-title":"Autologous conjunctival epithelium transplantation and scleral patch graft for postlensectomy wound leakage in Marfan syndrome","volume":"22","author":"Mancino","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"2025082711210772000_15.8.e249990.9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000503440","article-title":"Occult spontaneous ocular perforation presenting as conjunctival Chemosis in a patient with Marfan's syndrome","volume":"10","author":"Voulgari","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"2025082711210772000_15.8.e249990.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00993-X"},{"key":"2025082711210772000_15.8.e249990.11","doi-asserted-by":"crossref","unstructured":"Oyewole KT , Shortt AJ , Ramkissoon Y . Simultaneous extrusion and intrusion of a scleral buckle in a patient with Marfan\u2019s syndrome. BMJ Case Rep 2011.doi:10.1136\/bcr.08.2009.2182","DOI":"10.1136\/bcr.08.2009.2182"},{"key":"2025082711210772000_15.8.e249990.12","unstructured":"Kanski\u2019s Clinical Ophthalmology - 8th Edition [Internet]. Available: https:\/\/www.elsevier.com\/books\/kanskis-clinical-ophthalmology\/kanski\/978-0-7020-5572-0 [Accessed 7 Apr 2021]."},{"key":"2025082711210772000_15.8.e249990.13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/sj.eye.6702344","article-title":"Structural and functional outcome of scleral patch graft","volume":"21","author":"Sangwan","year":"2007","journal-title":"Eye"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-249990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:21:14Z","timestamp":1756318874000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-249990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,30]]},"published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1136\/bcr-2022-249990"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-249990","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}