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CT revealed an infiltrative mass invading the ethmoidal sinuses, frontal sinuses and both orbits. A histological diagnosis of infiltrative ductal breast carcinoma was made after nasal endoscopic and left breast biopsy. She underwent palliative chemoradiotherapy and survived with good disease control after 1\u2009year. Metastatic carcinoma is a differential diagnosis of a sino-orbital mass, and comprehensive clinical assessment is indicated for all patients presenting with non-acute eye injury.<\/jats:p>","DOI":"10.1136\/bcr-2022-250108","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T10:00:23Z","timestamp":1668160823000},"page":"e250108","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sino-orbital metastasis as the initial presentation of advanced breast cancer"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-9645","authenticated-orcid":false,"given":"Mohamad Kamil","family":"Muhammad-Ikmal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurul 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