{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:53Z","timestamp":1783948853826,"version":"3.55.0"},"reference-count":9,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,10,13]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. The constellation of findings of unprovoked fractures, hypophosphataemia, urinary phosphate wasting and a negative genetic evaluation suggest a TIO diagnosis. Tumours leading to TIO are often small and difficult to localise using standard imaging studies. The <jats:sup>68<\/jats:sup>Ga-DOTATATE CT\/positron emission tomography, a somatostatin receptor imaging modality, is the radiographical study of choice for localisation. It is highly sensitive and specific since tumours that cause oncogenic osteomalacia have been shown to express somatostatin receptors. Complete surgical resection is the treatment of choice; however, it may not always be feasible. Burosumab, a human anti-fibroblast growth factor-23 monoclonal antibody, is a therapeutic option in cases of unresectable TIO to normalise phosphorus levels and improve fracture healing. Our patient was initiated on burosumab, which led to healing of his fractures and profound symptomatic improvement of his pain. TIO is often undiagnosed for many years, leading to significant patient morbidity.<\/jats:p>","DOI":"10.1136\/bcr-2022-250237","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T10:00:13Z","timestamp":1668074413000},"page":"e250237","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Tumour-induced osteomalacia due to residual benign glomangioma"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-1808","authenticated-orcid":false,"given":"Rakhee","family":"Barai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-5683","authenticated-orcid":false,"given":"Tiffany","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-2724","authenticated-orcid":false,"given":"Lissette","family":"Cespedes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"2025082622470503000_15.11.e250237.1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0006"},{"key":"2025082622470503000_15.11.e250237.2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.4233","article-title":"Burosumab for the treatment of tumor-induced osteomalacia","volume":"36","author":"Jan de Beur","year":"2021","journal-title":"J Bone Miner Res"},{"key":"2025082622470503000_15.11.e250237.3","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/jbmr.4318","article-title":"Burosumab for tumor-induced osteomalacia: not enough of a good thing","volume":"36","author":"Hartley","year":"2021","journal-title":"J Bone Miner Res"},{"key":"2025082622470503000_15.11.e250237.4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00223-020-00691-6","article-title":"Tumor-Induced osteomalacia","volume":"108","author":"Florenzano","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"2025082622470503000_15.11.e250237.5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.afos.2018.12.001","article-title":"Tumor-Induced osteomalacia","volume":"4","author":"Yin","year":"2018","journal-title":"Osteoporos Sarcopenia"},{"key":"2025082622470503000_15.11.e250237.6","doi-asserted-by":"crossref","unstructured":"Yang M . Current problems in diagnostic radiology 2019;48:379\u201386.","DOI":"10.1067\/j.cpradiol.2018.06.005"},{"key":"2025082622470503000_15.11.e250237.7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.clinimag.2019.04.007","article-title":"Tumor-Induced osteomalacia \u2013 current imaging modalities and a systematic approach for tumor localization","volume":"56","author":"Rayamajhi","year":"2019","journal-title":"Clin Imaging"},{"key":"2025082622470503000_15.11.e250237.8","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1055\/s-0036-1597599","article-title":"Anterior skull base Glomangioma-Induced osteomalacia","volume":"78","author":"Gresham","year":"2017","journal-title":"J Neurol Surg Rep"},{"key":"2025082622470503000_15.11.e250237.9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/jbmr.4280","article-title":"Tumor-Induced osteomalacia: treatment progress using Burosumab, an Anti-FGF23 monoclonal antibody","volume":"36","author":"Whyte","year":"2021","journal-title":"J Bone Miner Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-250237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:47:17Z","timestamp":1756273637000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-250237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":9,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,10]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-250237"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-250237","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}