{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:40:16Z","timestamp":1756305616159,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,14]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Scleromyxoedema is a rare mucinosis that primarily affects the skin. It is associated with monoclonal gammopathy and has many extracutaneous manifestations, however, renal involvement is rare. We report the case of a woman with monoclonal gammopathy and scleromyxoedema presenting with progressive exertional dyspnoea and acute renal failure. Workup of her renal failure revealed monoclonal gammopathy associated C3 glomerulonephritis. She was treated with intravenous steroids and discharged with plans to pursue annual monoclonal gammopathy laboratory monitoring. Given the rarity of renal scleromyxoedema, careful investigation of extracutaneous manifestations and comorbidities is critical to discern the primary pathological process in patients with scleromyxoedema who develop renal insufficiency.<\/jats:p>","DOI":"10.1136\/bcr-2022-250296","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T10:25:12Z","timestamp":1669803912000},"page":"e250296","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Renal injury in scleromyxoedema due to monoclonal gammopathy associated C3 glomerulonephritis"],"prefix":"10.1136","volume":"15","author":[{"given":"Stephanie","family":"Kao","sequence":"first","affiliation":[{"name":"Department of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia D","family":"Silinsky Krupnikova","sequence":"additional","affiliation":[{"name":"Arthritis and Rheumatism Associates, PC, Wheaton, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"AlMackenzie","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Medical Cities of the Ministry of the Interior, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gelareh","family":"Atefi","sequence":"additional","affiliation":[{"name":"Immunology, AstraZeneca, Wilmington, Delaware, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"2025082707072029000_15.11.e250296.1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/RHU.0b013e31822be61e","article-title":"Scleroderma renal crisis-like acute renal failure associated with mucopolysaccharide accumulation in renal vessels in a patient with scleromyxedema","volume":"17","author":"Lee","year":"2011","journal-title":"J Clin Rheumatol"},{"key":"2025082707072029000_15.11.e250296.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709974"},{"key":"2025082707072029000_15.11.e250296.3","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111630"},{"key":"2025082707072029000_15.11.e250296.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01565.x"},{"key":"2025082707072029000_15.11.e250296.5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0190-9622(86)70104-7","article-title":"Scleromyxedema associated with scleroderma renal disease and acute psychosis","volume":"14","author":"Kantor","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"2025082707072029000_15.11.e250296.6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm103"},{"key":"2025082707072029000_15.11.e250296.7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm354"},{"key":"2025082707072029000_15.11.e250296.8","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90007-1"},{"key":"2025082707072029000_15.11.e250296.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.07.011"},{"key":"2025082707072029000_15.11.e250296.10","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/jdv.14466","article-title":"European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, part 2: scleromyxedema, scleredema and nephrogenic systemic fibrosis","volume":"31","author":"Knobler","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025082707072029000_15.11.e250296.11","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.045328"},{"key":"2025082707072029000_15.11.e250296.12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.212"},{"key":"2025082707072029000_15.11.e250296.13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07110810"},{"key":"2025082707072029000_15.11.e250296.14","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.370"},{"key":"2025082707072029000_15.11.e250296.15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06180710"},{"key":"2025082707072029000_15.11.e250296.16","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/0886022X.2021.1990949","article-title":"C3 glomerulonephritis associated with monoclonal gammopathy: a retrospective case series study from a single institute in China","volume":"43","author":"Zhang","year":"2021","journal-title":"Ren Fail"},{"key":"2025082707072029000_15.11.e250296.17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.4.939"},{"key":"2025082707072029000_15.11.e250296.18","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.4049\/jimmunol.163.8.4590","article-title":"Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H","volume":"163","author":"Jokiranta","year":"1999","journal-title":"J Immunol"},{"key":"2025082707072029000_15.11.e250296.19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.20344\/amp.13823","article-title":"C3 glomerulonephritis associated with monoclonal gammopathy of renal significance","volume":"34","author":"Gomes-Alves","year":"2021","journal-title":"Acta Med Port"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-250296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:07:31Z","timestamp":1756303651000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-250296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,30]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-250296"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-250296","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}