{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:06:41Z","timestamp":1779109601734,"version":"3.51.4"},"reference-count":22,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,9,1]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>A man in his 60s with penetrating ileocolonic Crohn\u2019s disease (CD), recently started on ustekinumab therapy, presented with new onset dyspnoea, paroxysmal nocturnal dyspnoea and dependent oedema. He was diagnosed with heart failure (HF) 10 months after starting ustekinumab therapy. His symptoms resolved with discontinuation of ustekinumab and he had recovery of his cardiac function. Though initial studies that led to the U.S Food and Drug Administration (FDA)approval for ustekinumab did not detect a signal for HF, postmarketing surveillance has detected rare cases of HF after initiation of the medication. This is one of the few reported cases of HF associated with ustekinumab therapy for CD.<\/jats:p>","DOI":"10.1136\/bcr-2022-250376","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T11:51:11Z","timestamp":1663674671000},"page":"e250376","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Heart failure associated with ustekinumab therapy for treatment of Crohn\u2019s Disease"],"prefix":"10.1136","volume":"15","author":[{"given":"Erica","family":"Morgenweck","sequence":"first","affiliation":[{"name":"Gastroenterology, Naval Medical Center San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Park","sequence":"additional","affiliation":[{"name":"Gastroenterology, Naval Medical Center San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Bower","sequence":"additional","affiliation":[{"name":"Gastroenterology, Naval Medical Center San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2025082623524897000_15.9.e250376.1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.3.6.17815"},{"key":"2025082623524897000_15.9.e250376.2","first-page":"1035","article-title":"Severe cardiomyopathy induced by adalimumab administration for crohn\u2019s disease","volume":"5","author":"Toufaily","year":"2020","journal-title":"Austin Cardio & Cardiovascular Case Reports"},{"key":"2025082623524897000_15.9.e250376.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp132"},{"key":"2025082623524897000_15.9.e250376.4","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.903.4"},{"key":"2025082623524897000_15.9.e250376.5","doi-asserted-by":"crossref","first-page":"s39","DOI":"10.2741\/962","article-title":"Human viral cardiomyopathy","volume":"8","author":"Maisch","year":"2003","journal-title":"Front Biosci"},{"key":"2025082623524897000_15.9.e250376.6","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.27"},{"key":"2025082623524897000_15.9.e250376.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"2025082623524897000_15.9.e250376.8","first-page":"80","article-title":"Possible heart failure associated with pregabalin use: case report","volume":"23","author":"Erdo\u011fan","year":"2011","journal-title":"Agri"},{"key":"2025082623524897000_15.9.e250376.9","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L031"},{"key":"2025082623524897000_15.9.e250376.10","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082623524897000_15.9.e250376.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"2025082623524897000_15.9.e250376.12","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00589-7"},{"key":"2025082623524897000_15.9.e250376.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00268-9"},{"key":"2025082623524897000_15.9.e250376.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9168-4"},{"key":"2025082623524897000_15.9.e250376.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.05.004"},{"key":"2025082623524897000_15.9.e250376.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"2025082623524897000_15.9.e250376.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"2025082623524897000_15.9.e250376.18","unstructured":"Data from: STELARA \u2013 occurrence of congestive heart failure. Janssen MD professional information resource, 2021. Available: https:\/\/www.janssenmd.com\/stelara\/safety\/heart-failure\/stelara-occurrence-of-congestive-heart-failure"},{"key":"2025082623524897000_15.9.e250376.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04500.x"},{"key":"2025082623524897000_15.9.e250376.20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdds.2015.03.003","article-title":"A case report of heart failure after therapy with ustekinumab","volume":"19","author":"Beroukhim","year":"2015","journal-title":"Journal of Dermatology & Dermatologic Surgery"},{"key":"2025082623524897000_15.9.e250376.21","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1001\/jamadermatol.2020.2977","article-title":"Association between early severe cardiovascular events and the initiation of treatment with the Anti-Interleukin 12\/23p40 antibody ustekinumab","volume":"156","author":"Poizeau","year":"2020","journal-title":"JAMA Dermatol"},{"key":"2025082623524897000_15.9.e250376.22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.670398","article-title":"Adverse events associated with anti-il-23 agents: clinical evidence and possible mechanisms","volume":"12","author":"Ru","year":"2021","journal-title":"Front Immunol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-250376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:53:01Z","timestamp":1756277581000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-250376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,20]]},"published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1136\/bcr-2022-250376"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-250376","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}