{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:40Z","timestamp":1756339480655,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,2,17]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>We report a rare case of takotsubo cardiomyopathy caused by subacute thyroiditis in a man in his 50s. He went to the doctor with complaints of loss of appetite, diarrhoea, chills and general malaise. He had consciousness disturbance, thyrotoxicosis and thyroid-stimulating hormone (TSH) suppression. Thyroglobulin and C reactive protein levels in the blood were elevated, but TSH receptor antibody, thyroid-stimulating antibody, antithyroglobulin antibody and antithyroid peroxidase antibody were not. We began treatment with prednisolone and propranolol after he was diagnosed with thyroid storm caused by subacute thyroiditis. The ECG revealed inverted T waves on the fifth day after admission. He was newly diagnosed with takotsubo cardiomyopathy on the day. A large thrombus was detected in the left ventricle, requiring anticoagulation therapy. Thus, even if there are no findings of takotsubo cardiomyopathy or thrombus at the onset of thyroid storm, appropriate monitoring is required because they can develop during the treatment course.<\/jats:p>","DOI":"10.1136\/bcr-2022-250540","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T10:22:07Z","timestamp":1678789327000},"page":"e250540","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis"],"prefix":"10.1136","volume":"16","author":[{"given":"Daichi","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Osaki","sequence":"additional","affiliation":[{"name":"Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Shimano","sequence":"additional","affiliation":[{"name":"Internal Medicine (Endocrinology and Metabolism), University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"2025082708001864000_16.3.e250540.1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009003","article-title":"Association of endocrine conditions with takotsubo cardiomyopathy: a comprehensive review","volume":"7","author":"Gupta","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2025082708001864000_16.3.e250540.2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0334"},{"key":"2025082708001864000_16.3.e250540.3","unstructured":"Japan thyroid association . Guideline for the diagnosis of subacute thyroiditis (acute phase). 2010. Available: www.japanthyroid.jp\/doctor\/guideline\/english.html#akyuu [Accessed 13 Apr 2022]."},{"key":"2025082708001864000_16.3.e250540.4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijscr.2017.02.041","article-title":"Subacute thyroiditis causing thyrotoxic crisis; a case report with literature review","volume":"33","author":"Salih","year":"2017","journal-title":"Int J Surg Case Rep"},{"key":"2025082708001864000_16.3.e250540.5","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0140"},{"key":"2025082708001864000_16.3.e250540.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl032"},{"key":"2025082708001864000_16.3.e250540.7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl570"},{"key":"2025082708001864000_16.3.e250540.8","doi-asserted-by":"publisher","DOI":"10.1253\/circj.68.77"},{"key":"2025082708001864000_16.3.e250540.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"2025082708001864000_16.3.e250540.10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006990","article-title":"Left ventricular thrombi in takotsubo syndrome: incidence, predictors, and management: results from the GEIST (German Italian stress cardiomyopathy) registry","volume":"6","author":"Santoro","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2025082708001864000_16.3.e250540.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.5.1435"},{"key":"2025082708001864000_16.3.e250540.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0199"},{"key":"2025082708001864000_16.3.e250540.13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4103\/ijem.IJEM_583_17","article-title":"Study on coagulation factor VIII and fibrinogen levels in patients with thyroid disorders","volume":"22","author":"Thoyyib","year":"2018","journal-title":"Indian J Endocrinol Metab"},{"key":"2025082708001864000_16.3.e250540.14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000381769","article-title":"Effect of experimental thyrotoxicosis onto blood coagulation: a proteomics study","volume":"4","author":"Engelmann","year":"2015","journal-title":"Eur Thyroid J"},{"key":"2025082708001864000_16.3.e250540.15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306853"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-250540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:00:24Z","timestamp":1756306824000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-250540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3,14]]},"published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1136\/bcr-2022-250540"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-250540","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}