{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:21:44Z","timestamp":1771474904143,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,29]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Conjunctival amelanotic malignant melanoma is a rare form of melanoma, which lacks visible pigment and is commonly located underneath the eyelids in the bulbar conjunctiva. In this report, we described a case of a Caucasian women in her 70s who presented with unilateral irritation and tenderness following cataract surgery. On eversion of the eyelid, two elevated pink lesions were noted. Tumour - Node - Metastasis staging with the American Joint Committee on Cancer staging system eighth edition was T3C and required multiple excisions and reconstruction procedures. This case exemplified the diagnostic pitfall of conjunctival amelanotic malignant melanoma, which is a potentially life-threatening disease and the importance of histopathology in the diagnostic process.<\/jats:p>","DOI":"10.1136\/bcr-2022-250682","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T10:30:49Z","timestamp":1670409049000},"page":"e250682","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Conjunctival amelanotic melanoma presenting as a multifocal pink lesion"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-6919","authenticated-orcid":false,"given":"Matthew Keith","family":"Kenworthy","sequence":"first","affiliation":[{"name":"Ophthalmology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Jane","family":"Kenworthy","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University\u2014Geelong Waurn Ponds Campus, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"De Guzman","sequence":"additional","affiliation":[{"name":"Hamatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Morlet","sequence":"additional","affiliation":[{"name":"Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"2025082623042442000_15.12.e250682.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.49.4.169"},{"key":"2025082623042442000_15.12.e250682.2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.2.167"},{"key":"2025082623042442000_15.12.e250682.3","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32823ecfbb"},{"key":"2025082623042442000_15.12.e250682.4","first-page":"61","article-title":"Primary acquired melanosis of the conjunctiva: experience with 311 eyes","volume":"105","author":"Shields","year":"2007","journal-title":"Trans Am Ophthalmol Soc"},{"key":"2025082623042442000_15.12.e250682.5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/eye.2012.254","article-title":"Conjunctival melanoma and melanocytic intra-epithelial neoplasia","volume":"27","author":"Kenawy","year":"2013","journal-title":"Eye"},{"key":"2025082623042442000_15.12.e250682.6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ajo.2020.10.020","article-title":"Validation of the newly proposed World Health organization classification system for conjunctival melanocytic intraepithelial lesions: a comparison with the C-MIN and PAM classification schemes","volume":"223","author":"Milman","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"2025082623042442000_15.12.e250682.7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/jamaophthalmol.2015.6122","article-title":"Conjunctival Lymphoma--An International Multicenter Retrospective Study","volume":"134","author":"Kirkegaard","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"2025082623042442000_15.12.e250682.8","unstructured":"Nepveu G , Bernard C . Contribution \u00e0 l'\u00e9tude des tumeurs m\u00e9laniques: m\u00e9moire communiqu\u00e9 \u00e0 la Soci\u00e9t\u00e9 de Biologie en mai 1872. Paris; 1872. 4-5p. Available: http:\/\/resource.nlm.nih.gov\/101748854"},{"key":"2025082623042442000_15.12.e250682.9","first-page":"3399","article-title":"Population-Based assessment of clinical characteristics predicting outcome of conjunctival melanoma in whites","volume":"43","author":"Tuomaala","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025082623042442000_15.12.e250682.10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.157933"},{"key":"2025082623042442000_15.12.e250682.11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0344"},{"key":"2025082623042442000_15.12.e250682.12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s12253-018-0419-3","article-title":"Conjunctival Melanoma - Epidemiological Trends and Features","volume":"24","author":"Ka\u0161telan","year":"2018","journal-title":"Pathol Oncol Res"},{"key":"2025082623042442000_15.12.e250682.13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.11.1497"},{"key":"2025082623042442000_15.12.e250682.14","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316293"},{"key":"2025082623042442000_15.12.e250682.15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312018"},{"key":"2025082623042442000_15.12.e250682.16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1586\/17469899.2014.921119","article-title":"Management of conjunctival malignant melanoma: a review and update","volume":"9","author":"Wong","year":"2014","journal-title":"Expert Rev Ophthalmol"},{"key":"2025082623042442000_15.12.e250682.17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00002341-200005000-00003","article-title":"Clinical features predictive of orbital exenteration for conjunctival melanoma","volume":"16","author":"Shields","year":"2000","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025082623042442000_15.12.e250682.18","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.7.520"},{"key":"2025082623042442000_15.12.e250682.19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/jamaophthalmol.2017.2279","article-title":"Pembrolizumab for recurrent conjunctival melanoma","volume":"135","author":"Kini","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"2025082623042442000_15.12.e250682.20","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0555-7"},{"key":"2025082623042442000_15.12.e250682.21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/aos.13100","article-title":"Conjunctival malignant melanoma in Denmark: epidemiology, treatment and prognosis with special emphasis on tumorigenesis and genetic profile","volume":"94 Thesis 1","author":"Larsen","year":"2016","journal-title":"Acta Ophthalmol"},{"key":"2025082623042442000_15.12.e250682.22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0344"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-250682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:04:37Z","timestamp":1756274677000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-250682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,7]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bcr-2022-250682"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-250682","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}