{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:45:30Z","timestamp":1774673130091,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,9,6]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Nasopharyngeal carcinoma can present with epistaxis, cervical lymphadenopathy, audiological symptoms secondary to eustachian tube dysfunction, pain, or neurological symptoms from tumours directly invading the skull base. It is unusual for patients to present with indirect systemic manifestations. Paraneoplastic neurological syndrome can precede clinically overt malignancy by up to 5 years; therefore, a combination of thorough clinical, laboratory and radiological investigations is required to reach a diagnosis. Intravenous immunoglobulin and steroids might improve neurological symptoms initially and prevent irreversible neuronal damage, but treatment of the underlying cancer is important for long-term resolution. Our case adds to a small but growing body of literature related to anti-Ri antibodies, opsoclonus-myoclonus syndrome presentations, and is the first reported association of this combination with nasopharyngeal carcinoma.<\/jats:p>","DOI":"10.1136\/bcr-2022-250871","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T10:11:03Z","timestamp":1666779063000},"page":"e250871","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-9868","authenticated-orcid":false,"given":"Kirsten E","family":"Stewart","sequence":"first","affiliation":[{"name":"University of Dundee School of Medicine, Dundee, UK"},{"name":"Department of Otolaryngology, NHS Fife, Kirkcaldy, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Department of Neurology, NHS Fife, Kirkcaldy, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devraj","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Oncology, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C L","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, NHS Fife, Kirkcaldy, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"2025082804130668000_15.10.e250871.1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/0972-2327.93267","article-title":"Paraneoplastic neurologic syndrome: a practical approach","volume":"15","author":"Kannoth","year":"2012","journal-title":"Ann Indian Acad Neurol"},{"key":"2025082804130668000_15.10.e250871.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.224105rep"},{"key":"2025082804130668000_15.10.e250871.3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.anl.2008.10.006","article-title":"Paraneoplastic syndromes in patients with nasopharyngeal cancer","volume":"36","author":"Toro","year":"2009","journal-title":"Auris Nasus Larynx"},{"key":"2025082804130668000_15.10.e250871.4","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1007\/s12311-019-01045-1","article-title":"Paraneoplastic cerebellar degeneration in nasopharyngeal carcinoma: a unique association","volume":"18","author":"Bhardwaj","year":"2019","journal-title":"Cerebellum"},{"key":"2025082804130668000_15.10.e250871.5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.21315\/mjms2017.24.1.12","article-title":"Paraneoplastic neurological disorder in nasopharyngeal carcinoma","volume":"24","author":"Ng","year":"2017","journal-title":"Malays J Med Sci"},{"key":"2025082804130668000_15.10.e250871.6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11060-006-9204-3","article-title":"Paraneoplastic motor neuropathy and inflammatory myopathy associated with nasopharyngeal carcinoma","volume":"81","author":"Chan","year":"2007","journal-title":"J Neurooncol"},{"key":"2025082804130668000_15.10.e250871.7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/acn3.328","article-title":"Paraneoplastic cerebellar degeneration with anti-Yo antibodies - 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