{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:04Z","timestamp":1756363204342,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,13]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Lambert-Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disorder. Underlying small cell lung cancer is found in more than half of patients. Proximal muscle weakness, autonomic features and areflexia are typical manifestations. However, LEMS is often misdiagnosed. We report a rare case of paraneoplastic LEMS, identified amid admission due to a different diagnosis. Our patient was initially admitted due to aspiration pneumonia. Further investigation revealed clinical and electrophysiological manifestations of LEMS. High clinical suspicion and early diagnostic workup were paramount in the patient outcome. Nevertheless, paraneoplastic aetiology was difficult to confirm and revealed itself a difficult challenge. Clinical awareness is crucial to diagnose LEMS and urge cancer screening and early treatment.<\/jats:p>","DOI":"10.1136\/bcr-2022-250947","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T10:36:00Z","timestamp":1674815760000},"page":"e250947","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Paraneoplastic Lambert-Eaton myasthenic syndrome: a diagnostic challenge"],"prefix":"10.1136","volume":"16","author":[{"given":"Lu\u00edsa","family":"Viveiros","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Raquel","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Xavier","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio do Porto, EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"2025082723111380000_16.1.e250947.1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0140-6736(53)91358-0","article-title":"Bronchial neoplasm with myasthenia; prolonged apnoea after administration of succinylcholine","volume":"265","author":"Anderson","year":"1953","journal-title":"Lancet"},{"key":"2025082723111380000_16.1.e250947.2","first-page":"612","article-title":"Defect of neuromuscular conduction associated with malignant neoplasms","volume":"187","author":"Lambert","year":"1956","journal-title":"Am J Physiol"},{"key":"2025082723111380000_16.1.e250947.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02970480021005"},{"key":"2025082723111380000_16.1.e250947.4","unstructured":"Jayarangaiah A , Theetha Kariyanna P . StatPearls. In: Lambert Eaton Myasthenic Syndrome. 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