{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:14Z","timestamp":1756339514904,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,18]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>We present the case of an HIV-negative man in his 50s who developed a generalised nodular rash while having first-line bortezomib\u2013cyclophosphamide\u2013dexamethasone chemotherapy for multiple myeloma. The rash was biopsied and proven to be Kaposi\u2019s sarcoma. The patient\u2019s treatment was interrupted at the sixth cycle of chemotherapy, by which time the rash had also spread to the oral mucosa and eyelid. The rash regressed spontaneously on stopping treatment. We were reluctant to restart myeloma treatment, but on the other hand, we wished to consolidate the very good partial response achieved. An autologous marrow transplant was done months later without any recurrence of his Kaposi\u2019s with the initiation of bortezomib maintenance. Bortezomib has putative activity against Kaposi\u2019s. The patient could benefit from imid-based (thalidomide, lenalidomide, pomalidomide) combination chemotherapy once his myeloma progresses or if there is a recurrence of Kaposi\u2019s sarcoma.<\/jats:p>","DOI":"10.1136\/bcr-2022-251044","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:35:26Z","timestamp":1685615726000},"page":"e251044","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Iatrogenic Kaposi\u2019s sarcoma from induction therapy for myeloma: to transplant or not to transplant?"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-5157","authenticated-orcid":false,"given":"Daniel","family":"Farrugia","sequence":"first","affiliation":[{"name":"Haematology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Sultana","sequence":"additional","affiliation":[{"name":"Haematology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Babic","sequence":"additional","affiliation":[{"name":"Histopathology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Grech","sequence":"additional","affiliation":[{"name":"Haematology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2025082708343060000_16.6.e251044.1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01830024","article-title":"Idiopathisches multiples Pigmentsarkomen der Haut","volume":"4","author":"Kaposi","year":"1872","journal-title":"Arch f Dermat"},{"key":"2025082708343060000_16.6.e251044.2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41409-019-0644-8","article-title":"Incidence and outcome of Kaposi sarcoma after hematopoietic stem cell transplantation: a retrospective analysis and a review of the literature, on behalf of infectious diseases working party of EBMT","volume":"55","author":"Cesaro","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"2025082708343060000_16.6.e251044.3","first-page":"375","article-title":"Human herpesvirus 8 (HHV-8\/KSHV) and hematologic malignancies","volume":"7","author":"Malnati","year":"2003","journal-title":"Rev Clin Exp Hematol"},{"key":"2025082708343060000_16.6.e251044.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5320.1851"},{"key":"2025082708343060000_16.6.e251044.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/123297","article-title":"Is there any relationship between human herpesvirus-8 and multiple myeloma","volume":"2013","author":"Sadeghian","year":"2013","journal-title":"Lymphoma"},{"key":"2025082708343060000_16.6.e251044.6","first-page":"95","article-title":"Correlation between human herpes virus 8 (Hhv8-) and plasma cell myeloma: a systematic review","volume":"5","author":"Sadeghian","year":"2018","journal-title":"Reviews in Clinical Medicine"},{"key":"2025082708343060000_16.6.e251044.7","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2340\/00015555-2727","article-title":"Bortezomib does not prevent the occurrence of Kaposi\u2019s sarcoma in patients with haematological malignancies: two case reports","volume":"97","author":"Chavarot","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"2025082708343060000_16.6.e251044.8","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3283499c37"},{"key":"2025082708343060000_16.6.e251044.9","unstructured":"National Cancer Institute . Clinical trial: bortezomib in treating patients with Relapsed or refractory AIDS-related Kaposi sarcoma. Clinicaltrials.Gov Identifier: Nct01016730 . n.d. Available: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01016730"},{"key":"2025082708343060000_16.6.e251044.10","doi-asserted-by":"crossref","first-page":"20476","DOI":"10.18632\/oncotarget.24944","article-title":"Impact of lenalidomide maintenance on the immune environment of multiple myeloma patients with low tumor burden after autologous stem cell transplantation","volume":"9","author":"Fostier","year":"2018","journal-title":"Oncotarget"},{"key":"2025082708343060000_16.6.e251044.11","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1200\/JCO.1989.7.9.1201","article-title":"Kaposi\u2019s sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. 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