{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:17:51Z","timestamp":1786565871778,"version":"build-2736575974"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,2,4]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>A woman in her early 20s presented with cough and fever. She had undergone an abdominal myomectomy 3\u2009years ago for uterine leiomyoma. Chest CT and positron emission tomography-CT revealed multiple round nodules in both lungs, suggesting metastatic lesions. A CT-guided lung biopsy was performed, and the tumour was diagnosed as pulmonary benign metastasising leiomyoma (PBML) based on pathological analyses. Whole exon capture sequencing of uterine leiomyoma and PBML sections revealed that 13 genes (MCM10, SLC16A9, RAG1, BAZ1A, NLRP2, TRMT61B, CPXM1, NGLY1, SUCLG2, FAM13A, CAGE1, PHTF2 and ZDHHC2) were concurrently present in the two tumours. The patient was prescribed goserelin injections every 4\u2009weeks. The symptoms improved 2\u2009weeks after starting the treatment. The lung nodules considerably decreased in size after three courses of goserelin treatment. The nodular size continues to decrease with the treatment.<\/jats:p>","DOI":"10.1136\/bcr-2022-251072","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:35:50Z","timestamp":1679481350000},"page":"e251072","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Whole exon capture sequencing for identifying mutations associated with pulmonary benign metastasising leiomyoma"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-8625","authenticated-orcid":false,"given":"Zhijun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, 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