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The patient was on ripasudil 0.4% for the past 4\u2009months prior to the presentation. Honeycomb epithelial oedema was seen with vesicles and intraepithelial microcyst formation which were also noted on anterior segment optical coherence tomography (OCT) and histopathology, that co-related with the slit-lamp findings. The patient underwent repeat DSAEK and had a good outcome. While the clinical features and OCT findings have been reported earlier, the histopathological features have not been reported.<\/jats:p>","DOI":"10.1136\/bcr-2022-251074","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T12:49:32Z","timestamp":1658839772000},"page":"e251074","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Honeycomb epithelial oedema due to ripasudil: clinical, optical coherence tomography and histopathological correlation"],"prefix":"10.1136","volume":"15","author":[{"given":"Neha","family":"Jain","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment Service, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cornea and anterior segment, Angel Eyes Institute of Ophthalmology, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip K","family":"Mishra","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology Service, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-9669","authenticated-orcid":false,"given":"Somasheila I","family":"Murthy","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Service, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"2025082710532021000_15.7.e251074.1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.ophtha.2018.04.040","article-title":"Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension","volume":"125","author":"Tanna","year":"2018","journal-title":"Ophthalmology"},{"key":"2025082710532021000_15.7.e251074.2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5078079"},{"key":"2025082710532021000_15.7.e251074.3","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000307"},{"key":"2025082710532021000_15.7.e251074.4","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/ICO.0000000000002621","article-title":"Transient reticular cystic corneal epithelial edema with topical netarsudil: a case series and review","volume":"40","author":"LoBue","year":"2021","journal-title":"Cornea"},{"key":"2025082710532021000_15.7.e251074.5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ogla.2019.01.001","article-title":"Netarsudil-associated reticular corneal epithelial edema with raised intraocular pressure","volume":"2","author":"Liu","year":"2019","journal-title":"Ophthalmol Glaucoma"},{"key":"2025082710532021000_15.7.e251074.6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/ICU.0000000000000579","article-title":"Descemet's stripping without endothelial keratoplasty","volume":"30","author":"Garcerant","year":"2019","journal-title":"Curr Opin Ophthalmol"},{"key":"2025082710532021000_15.7.e251074.7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18586"},{"key":"2025082710532021000_15.7.e251074.8","unstructured":"Tanihara H , Yamamoto T , Kuwayama Y . 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