{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:40:02Z","timestamp":1756316402337,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,8,7]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>A woman in her 40s presented with spells of hypertension, warmth, flushing and bradycardia for more than 1\u2009year. Despite normal plasma metanephrines of 0.48\u2009nmol\/L (reference range: &lt;0.50\u2009nmol\/L) and normal 24-hour urine metanephrines of 199 \u00b5g\/day (reference range: 52\u2013341 \u00b5g\/day), an abdominal CT scan was obtained which revealed a 1.7 \u00d7 1.4\u2009cm right adrenal gland nodule. During her next spell, 24-hour urine metanephrines were elevated at 585 \u00b5g\/day with total metanephrines of 1026 \u00b5g\/day (reference range: 140\u2013785 \u00b5g\/day). Subsequent MRI demonstrated a 1.5 \u00d7 1.5\u2009cm right adrenal gland lesion concerning for phaeochromocytoma. Right adrenal gland excision was performed and pathology confirmed a benign phaeochromocytoma. Follow-up genetic testing was negative. This case highlights the challenges of identifying phaeochromocytomas in the clinical setting. Early imaging may assist in the timely diagnosis and treatment of these tumours in patients presenting with recurrent spells and negative biochemical screening.<\/jats:p>","DOI":"10.1136\/bcr-2022-251113","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T11:01:18Z","timestamp":1661511678000},"page":"e251113","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Benign phaeochromocytoma presenting with recurrent spells and negative biochemical screening"],"prefix":"10.1136","volume":"15","author":[{"given":"Jamal","family":"Abukhaled","sequence":"first","affiliation":[{"name":"Department of Nephrology, Beaumont Health, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-7689","authenticated-orcid":false,"given":"Alexander Michael","family":"Balinski","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"2025082710250800000_15.8.e251113.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199101000-00004"},{"key":"2025082710250800000_15.8.e251113.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2000.tb04358.x"},{"key":"2025082710250800000_15.8.e251113.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-4-200102200-00016"},{"key":"2025082710250800000_15.8.e251113.4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1588"},{"key":"2025082710250800000_15.8.e251113.5","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.826.589"},{"key":"2025082710250800000_15.8.e251113.6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/HJH.0000000000001236","article-title":"High prevalence of cardiac electric abnormalities in patients with phaeochromocytomas","volume":"35","author":"Berra","year":"2017","journal-title":"J Hypertens"},{"key":"2025082710250800000_15.8.e251113.7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"2025082710250800000_15.8.e251113.8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0483"},{"key":"2025082710250800000_15.8.e251113.9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1210\/clinem\/dgaa794","article-title":"Recurrence rate of sporadic pheochromocytomas after curative adrenalectomy: a systematic review and meta-analysis","volume":"106","author":"Holscher","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082710250800000_15.8.e251113.10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1051"},{"key":"2025082710250800000_15.8.e251113.11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMra1806651","article-title":"Pheochromocytoma and paraganglioma","volume":"381","author":"Neumann","year":"2019","journal-title":"N Engl J Med"},{"key":"2025082710250800000_15.8.e251113.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2178"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:25:13Z","timestamp":1756315513000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,26]]},"published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1136\/bcr-2022-251113"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251113","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}