{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:40:10Z","timestamp":1756312810280,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,1,20]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>We present the case of a patient in his 80s receiving gemcitabine-cisplatin therapy for bladder cancer who developed neutropenia and was treated with filgrastim. In 10 days, the patient developed a mild fever with left jaw claudication and right knee arthritis. Contrast-enhanced CT findings indicated aortitis. Prednisolone was started for granulocyte colony-stimulating factor (G-CSF)-induced aortitis, and symptoms and elevated serum inflammatory markers resolved rapidly, allowing early discontinuation of prednisolone. Right knee arthritis relapsed at the initial follow-up. Contrast-enhanced CT revealed aortitis had disappeared. Therefore, recurrence of G-CSF-induced arthritis was suspected; prednisolone was resumed for 29 days without relapse. Most previous reports of G-CSF-induced aortitis have described inflammation of the aorta, carotid arteries and subclavian arteries; however, G-CSF-induced aortitis may present with more peripheral symptoms, such as temporal arteritis and knee arthritis. Furthermore, G-CSF-induced aortitis reportedly responds well and rapidly to prednisolone, although early discontinuation may lead to relapse.<\/jats:p>","DOI":"10.1136\/bcr-2022-251216","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T12:12:04Z","timestamp":1675771924000},"page":"e251216","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Granulocyte colony-stimulating factor-induced aortitis with temporal arteritis and monoarthritis"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-7254","authenticated-orcid":false,"given":"Keisuke","family":"Iida","sequence":"first","affiliation":[{"name":"General Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-8108","authenticated-orcid":false,"given":"Yuki","family":"Honda","sequence":"additional","affiliation":[{"name":"General Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-9078","authenticated-orcid":false,"given":"Yoichiro","family":"Homma","sequence":"additional","affiliation":[{"name":"General Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2025082709231247000_16.2.e251216.1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.autrev.2018.12.011","article-title":"G-csf-induced aortitis: two cases and review of the literature","volume":"18","author":"Parodis","year":"2019","journal-title":"Autoimmun Rev"},{"key":"2025082709231247000_16.2.e251216.2","doi-asserted-by":"crossref","DOI":"10.1093\/rap\/rkaa004","article-title":"Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review","volume":"4","author":"Taimen","year":"2020","journal-title":"Rheumatol Adv Pract"},{"key":"2025082709231247000_16.2.e251216.3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s10067-016-3253-6","article-title":"Isolated abdominal aortitis following administration of granulocyte colony stimulating factor (G-CSF)","volume":"35","author":"Miller","year":"2016","journal-title":"Clin Rheumatol"},{"key":"2025082709231247000_16.2.e251216.4","doi-asserted-by":"crossref","DOI":"10.1093\/ehjcr\/ytaa503","article-title":"Granulocyte colony stimulating factor-associated aortitis evaluated via multiple imaging modalities including vascular echography: a case report","volume":"5","author":"Harada","year":"2021","journal-title":"Eur Heart J Case Rep"},{"unstructured":"Japan Society of Clinical Oncology . 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