{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:02:16Z","timestamp":1793444536020,"version":"4.5.0"},"reference-count":29,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,10,31]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Patients with severe anaemia who refuse or cannot safely receive red cell transfusion present challenges during pregnancy, delivery and the postpartum period. Strategies including HBOC-201 (Hemopure) and intraoperative use of cell salvage have been used in non-pregnant patients to improve oxygen carrying capacity; however, these products pose unique risks in pregnant patients, those with sickle cell disease (SCD) and those undergoing caesarean section (C-section). We describe a case of a pregnant sickle beta+thalasasaemia patient who presented at 27 weeks gestation with pre-eclampsia and severe anaemia. As a Jehovah\u2019s Witness, she declined allogenic blood transfusion. The patient successfully underwent emergent C-section with cell salvage and received HBOC-201 immediately after delivery, during the operative procedure. To our knowledge, this is the first published report documenting a Jehovah\u2019s Witness patient with SCD who successfully received cell salvage and then HBOC-201 immediately postdelivery.<\/jats:p>","DOI":"10.1136\/bcr-2022-251368","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T09:20:10Z","timestamp":1668676810000},"page":"e251368","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Use of cell salvage and HBOC-201 in a pregnant Jehovah\u2019s Witness with sickle beta+thalassaemia undergoing emergency caesarean section"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3827-4088","authenticated-orcid":false,"given":"Julia","family":"Fortier","sequence":"first","affiliation":[{"name":"College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soleil","family":"Schutte","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Stuart","family":"Zumberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rajasekhar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"2025082622514984000_15.11.e251368.1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MOH.0000000000000535","article-title":"Transfusion support and alternatives for Jehovah's witness patients","volume":"26","author":"Crowe","year":"2019","journal-title":"Curr Opin Hematol"},{"key":"2025082622514984000_15.11.e251368.2","first-page":"1484","article-title":"Hboc-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery","volume":"64","author":"Jahr","year":"2008","journal-title":"Journal of Trauma: Injury, Infection Critical 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