{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:10Z","timestamp":1756339510434,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,3]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Congenital lobar emphysema (CLE)\/congenital alveolar overdistension\/congenital lobar overinflation or infantile lobar emphysema is a rare developmental anomaly of the lower respiratory tract which is characterised by hyperinflation of one or more of the pulmonary lobes. Histopathology may be variable, which may show abnormality in the cartilage, granulation tissue, mucosal folds, etc. We report a rare underlying histopathology in a preterm neonate with CLE. This entity referred to as pulmonary interstitial glycogenosis (PIG) is a group of heterogeneous lung disease affecting the lung parenchyma and is characterised by the presence of glycogen laden cells in the lung interstitium. This impairs the gas exchange and typically manifest as tachypnoea, retractions, hypoxia and increased respiratory support. Our case report highlights the association of CLE and PIG and a review of literature. One should always have a detailed histopathology in children presenting with CLE to rule out PIG.<\/jats:p>","DOI":"10.1136\/bcr-2022-251472","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:34:33Z","timestamp":1668512073000},"page":"e251472","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rare interstitial lung disease in a preterm neonate with congenital lobar emphysema"],"prefix":"10.1136","volume":"15","author":[{"given":"Swati","family":"Jayaram","sequence":"first","affiliation":[{"name":"Paediatrics, Case Western Reserve University Hospital, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Abramovich","sequence":"additional","affiliation":[{"name":"Pathology, Case Western Reserve University Hospital, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Roy","sequence":"additional","affiliation":[{"name":"Paediatrics, Case Western Reserve University Hospital, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-1827","authenticated-orcid":false,"given":"Gurinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Paediatrics, Case Western Reserve University Hospital, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2025082708264458000_15.11.e251472.1","doi-asserted-by":"crossref","DOI":"10.3390\/children7120280","article-title":"Children\u2019s Interstitial and Diffuse Lung Diseases (ChILD) in 2020","volume":"7","author":"Ferraro","year":"2020","journal-title":"Children"},{"key":"2025082708264458000_15.11.e251472.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201305-0923ST"},{"key":"2025082708264458000_15.11.e251472.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1730-7"},{"key":"2025082708264458000_15.11.e251472.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105139"},{"key":"2025082708264458000_15.11.e251472.5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.rmed.2018.05.009","article-title":"Pulmonary interstitial glycogenosis - A systematic analysis of new cases","volume":"140","author":"Seidl","year":"2018","journal-title":"Respir Med"},{"key":"2025082708264458000_15.11.e251472.6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.humpath.2017.06.026","article-title":"Pulmonary interstitial glycogenosis associated with a spectrum of neonatal pulmonary disorders","volume":"68","author":"Cutz","year":"2017","journal-title":"Hum Pathol"},{"key":"2025082708264458000_15.11.e251472.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2725"},{"key":"2025082708264458000_15.11.e251472.8","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1007\/s00247-018-4138-4","article-title":"High-resolution CT findings of pulmonary interstitial glycogenosis","volume":"48","author":"Weinman","year":"2018","journal-title":"Pediatr Radiol"},{"key":"2025082708264458000_15.11.e251472.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1670-2"},{"key":"2025082708264458000_15.11.e251472.10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/B978-0-323-02842-4.50064-4","volume-title":"Pediatric surgery","volume":"1-2","author":"Adzick","year":"2006"},{"key":"2025082708264458000_15.11.e251472.11","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.6084"},{"key":"2025082708264458000_15.11.e251472.12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2147\/COPD.S170581","article-title":"Congenital lobar emphysema: diagnosis and treatment options","volume":"14","author":"Demir","year":"2019","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2025082708264458000_15.11.e251472.13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jpedsurg.2017.01.056","article-title":"Bilateral congenital lobar emphysema: staged management","volume":"52","author":"Perea","year":"2017","journal-title":"J Pediatr Surg"},{"key":"2025082708264458000_15.11.e251472.14","doi-asserted-by":"crossref","unstructured":"Hilvers P et al . Coexistence of congenital lobar emphysema and pulmonary interstitial glycogenosis in a neonate. Am J Respir Crit Care Med 2010:A6737 https:\/\/www.atsjournals.org\/doi\/abs\/10.1164\/ajrccm-conference.2010.181.1_MeetingAbstracts.A6737","DOI":"10.1164\/ajrccm-conference.2010.181.1_MeetingAbstracts.A6737"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:26:53Z","timestamp":1756308413000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,15]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-251472"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251472","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}