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Comparison of similar sized deletions and duplications overlapping the same genes in the DECIPHER database, revealed seven reports of copy number variants (CNVs), four duplications and three deletions. A neurodevelopmental phenotype including learning disability and intellectual disability was noted in some of the DECIPHER entries where phenotype was provided. Although the association between a deletion in this region and an atypical neurodevelopmental trajectory remains to be elucidated, the overlapping CNVs with neurodevelopmental phenotypes suggests possible candidate genes within the 16p13.13 region.<\/jats:p>","DOI":"10.1136\/bcr-2022-251521","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T01:15:11Z","timestamp":1709169311000},"page":"e251521","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Global developmental delay and a de novo deletion of the 16p13.13 region"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-775X","authenticated-orcid":false,"given":"Aneta","family":"Krakowski","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, 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