{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:56:41Z","timestamp":1777564601826,"version":"3.51.4"},"reference-count":28,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,3,17]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Cutaneous lesions are common manifestation of congenital leukaemia especially myeloid type with incidence of 25%\u201350% in reported cases. It is relatively rare in transient abnormal myelopoiesis (TAM) seen in trisomy 21 (~10%). The rashes seen in leukaemia and TAM are different. We report a case with a rare presentation of confluent bullous eruption in a phenotypically normal neonate with trisomy 21 restricted to haematopoietic blast cells. This rash resolved rapidly after low-dose cytarabine therapy with normalisation of total white cell counts. The risk of Down syndrome-associated myeloid leukaemia in such cases is still high (19%\u201323%) in first 5\u2009years and rare thereafter.<\/jats:p>","DOI":"10.1136\/bcr-2022-251523","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:30:13Z","timestamp":1680863413000},"page":"e251523","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Bullous eruptions in transient abnormal myelopoiesis with normal phenotype"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-886X","authenticated-orcid":false,"given":"Madhusudhan Demahalli","family":"Shivamallappa","sequence":"first","affiliation":[{"name":"GRACE NICU, Children's Hospital at Westmead, Westmead, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mullins","sequence":"additional","affiliation":[{"name":"Oncology, Children's Hospital at 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