{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:49:01Z","timestamp":1760986141224,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,11]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>We present a previously well woman in her 70s who was admitted for 2\u2009weeks of progressively worsening abdominal pain, high fever and drowsiness. She was eventually diagnosed with <jats:italic>Clostridium septicum<\/jats:italic> brain abscess, meningoencephalitis and ventriculitis. The diagnosis was challenging as cerebrospinal fluid cultures were negative and a microbiological diagnosis was only obtained on brain biopsy. Despite early initiation of antibiotics that would have been effective against <jats:italic>C. septicum<\/jats:italic>, her central nervous system (CNS) infection progressed, and she eventually succumbed to the infection. Infections with <jats:italic>C. septicum<\/jats:italic> are typically fulminant and associated with high mortality. In a patient with a CNS infection and concomitant abdominal manifestations, infection with <jats:italic>C. septicum<\/jats:italic> should be considered.<\/jats:p>","DOI":"10.1136\/bcr-2022-251719","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T11:10:40Z","timestamp":1669029040000},"page":"e251719","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Clostridium septicum<\/i> brain abscess"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-5789","authenticated-orcid":false,"given":"Daryl Jian An","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin Chong Yu","family":"Sng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Changi General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi Wern","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"2025082712424151000_15.11.e251719.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1074"},{"key":"2025082712424151000_15.11.e251719.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02113607"},{"key":"2025082712424151000_15.11.e251719.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0524-9"},{"key":"2025082712424151000_15.11.e251719.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.06.2010.3106","article-title":"An unusual case of pneumocephalus","volume":"2011","author":"Bhogal","year":"2011","journal-title":"BMJ Case Rep"},{"key":"2025082712424151000_15.11.e251719.5","doi-asserted-by":"publisher","DOI":"10.1080\/00365540050166009"},{"key":"2025082712424151000_15.11.e251719.6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12028-015-0192-z","article-title":"Clostridium septicum pneumocephalus","volume":"24","author":"Katyal","year":"2016","journal-title":"Neurocrit Care"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:42:47Z","timestamp":1756323767000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":6,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,21]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-251719"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251719","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}