{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:10:03Z","timestamp":1756325403534,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,4,18]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Mesonephric remnants (MRs) are embryonic vestiges most commonly found in female pathology specimens from the lateral wall of the cervix. The highly regulated genetic programme of mesonephric duct development has been well characterised in animals based on traditional surgical castration and knockout mouse experiments. However, the process is incompletely understood in humans. MRs are believed to give rise to mesonephric neoplasms, which are rare tumours with uncertain pathophysiology. There is a dearth of molecular studies on mesonephric neoplasms in part due to their rarity. Here, we report the results of next-generation sequencing of MR, which identified amplification of the androgen receptor gene for the first time to the best of our knowledge and discuss the potential implications in the context of the literature.<\/jats:p>","DOI":"10.1136\/bcr-2022-251741","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:00:22Z","timestamp":1686304822000},"page":"e251741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Androgen receptor amplification in mesonephric remnants"],"prefix":"10.1136","volume":"16","author":[{"given":"Gulnaz","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Missouri Kansas City, Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Zara Rozalen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington DC VA Medical Center, Washington, District of Columbia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E","family":"Nava","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington DC VA Medical Center, Washington, District of Columbia, USA"},{"name":"Department of Pathology, The George Washington University, Washington, District of Columbia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2025082712335396000_16.6.e251741.1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/15476278.2016.1145318","article-title":"Studies of Gonadal sex differentiation","volume":"12","author":"Makiyan","year":"2016","journal-title":"Organogenesis"},{"key":"2025082712335396000_16.6.e251741.2","doi-asserted-by":"crossref","unstructured":"Montalvo N , Redrob\u00e1n L , Galarza D . Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis. 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