{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:57Z","timestamp":1756425837509,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,3,23]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Calcific uraemic arteriolopathy (CUA) is a rare and poorly understood entity that typically presents with painful lesions affecting adipose-rich areas of the lower extremities. We report an unusual case of CUA presenting as presumed cellulitis of the dorsal surface of the distal lower extremity with acute development of a bullous lesion. As CUA incidence is predicted to increase due to its relationship with end-stage renal disease, recognising the full clinical spectrum of this disease is essential to promote further understanding of this disorder and exploration of additional therapeutics to limit disease morbidity and mortality.<\/jats:p>","DOI":"10.1136\/bcr-2022-251758","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T13:27:22Z","timestamp":1680614842000},"page":"e251758","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Calcific uraemic arteriolopathy presenting as cellulitis of the dorsal foot"],"prefix":"10.1136","volume":"16","author":[{"given":"Samuel","family":"Ficenec","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Dale","family":"Shamburger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"2025082804033113000_16.4.e251758.1","first-page":"17","article-title":"Case of calcification of the arteries and obliterative endarteritis associated with hydronephrosis in a child aged six months","volume":"55","author":"Bryant","year":"1901","journal-title":"Guys Hosp Rep"},{"key":"2025082804033113000_16.4.e251758.2","first-page":"38","article-title":"Calciphylaxis","volume":"1","author":"Bhambri","year":"2008","journal-title":"J Clin Aesthet Dermatol"},{"key":"2025082804033113000_16.4.e251758.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.006"},{"key":"2025082804033113000_16.4.e251758.4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091065"},{"key":"2025082804033113000_16.4.e251758.5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.kint.2018.03.016","article-title":"Questionable specificity of histologic findings in calcific uremic arteriolopathy","volume":"94","author":"Ellis","year":"2018","journal-title":"Kidney Int"},{"key":"2025082804033113000_16.4.e251758.6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12882-020-01722-y","article-title":"Calciphylaxis epidemiology, risk factors, treatment and survival among french chronic kidney disease patients: a case-control study","volume":"21","author":"Gaisne","year":"2020","journal-title":"BMC Nephrol"},{"key":"2025082804033113000_16.4.e251758.7","doi-asserted-by":"crossref","first-page":"S724","DOI":"10.1007\/s11606-014-2910-1","article-title":"Quantifying a rare disease in administrative data: the example of calciphylaxis","volume":"29 Suppl 3","author":"Nigwekar","year":"2014","journal-title":"J Gen Intern Med"},{"key":"2025082804033113000_16.4.e251758.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.065"},{"key":"2025082804033113000_16.4.e251758.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00803.x"},{"key":"2025082804033113000_16.4.e251758.10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/089686089901900310","article-title":"Calcium use increases risk of Calciphylaxis: a case-control study","volume":"19","author":"Zacharias","year":"1999","journal-title":"Perit Dial Int"},{"key":"2025082804033113000_16.4.e251758.11","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90286-4"},{"key":"2025082804033113000_16.4.e251758.12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw025"},{"key":"2025082804033113000_16.4.e251758.13","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4103\/jfmpc.jfmpc_588_19","article-title":"Calciphylaxis and its diagnosis: a review","volume":"8","author":"Baby","year":"2019","journal-title":"J Family Med Prim Care"},{"key":"2025082804033113000_16.4.e251758.14","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31817792e4"},{"key":"2025082804033113000_16.4.e251758.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1.295"},{"key":"2025082804033113000_16.4.e251758.16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4158\/EP10349.RA","article-title":"Calciphylaxis due to hyperparathyroidism","volume":"17 Suppl 1","author":"Roy","year":"2011","journal-title":"Endocr Pract"},{"key":"2025082804033113000_16.4.e251758.17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00530108"},{"key":"2025082804033113000_16.4.e251758.18","doi-asserted-by":"publisher","DOI":"10.1177\/00220345680470065101"},{"key":"2025082804033113000_16.4.e251758.19","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1550-9"},{"key":"2025082804033113000_16.4.e251758.20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030964"},{"key":"2025082804033113000_16.4.e251758.21","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh080"},{"key":"2025082804033113000_16.4.e251758.22","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1210\/endo-71-4-554","article-title":"Sensitization to Calciphylaxis by endogenous parathyroid hormone","volume":"71","author":"Selye","year":"1962","journal-title":"Endocrinology"},{"key":"2025082804033113000_16.4.e251758.23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jdcr.2021.04.016","article-title":"The Koebner phenomenon may contribute to the development of Calciphylaxis: a case series","volume":"13","author":"Gabel","year":"2021","journal-title":"JAAD Case Rep"},{"key":"2025082804033113000_16.4.e251758.24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s40620-020-00908-9","article-title":"Calciphylaxis in end-stage kidney disease: outcome data from the United Kingdom Calciphylaxis study","volume":"34","author":"Chinnadurai","year":"2021","journal-title":"J Nephrol"},{"key":"2025082804033113000_16.4.e251758.25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.amjms.2015.11.015","article-title":"Calciphylaxis: controversies in pathogenesis, diagnosis and treatment","volume":"351","author":"Jeong","year":"2016","journal-title":"Am J Med Sci"},{"key":"2025082804033113000_16.4.e251758.26","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1001\/jamadermatol.2013.4565","article-title":"Intralesional sodium thiosulfate for the treatment of Calciphylaxis","volume":"149","author":"Strazzula","year":"2013","journal-title":"JAMA Dermatol"},{"key":"2025082804033113000_16.4.e251758.27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5414\/CNP75485","article-title":"Efficacy of sodium thiosulfate for the treatment for Calciphylaxis","volume":"75","author":"Noureddine","year":"2011","journal-title":"Clin Nephrol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:03:38Z","timestamp":1756379018000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4,4]]},"published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1136\/bcr-2022-251758"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251758","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}