{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:45:27Z","timestamp":1789825527858,"version":"4.0.1"},"reference-count":12,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,2]]},"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Rosai-Dorfman disease (RDD) is a rare and benign lymphoproliferative disorder that commonly presents as painless, bilateral neck swelling. Extranodal presentations are considered rare, but the most common extranodal locations involved include skin, subcutaneous followed by nasal\/paranasal sinuses. Although it is a benign condition, it may be mistaken as a malignant lesion and requires a biopsy for diagnostic confirmation. In this study, we report a rare case of RDD with bilateral neck node and nasal\/paranasal sinus involvement which initially presented with bilateral nasal obstruction. And, we reviewed the management in this unusual case and discussed the helpful role imaging studies play in the further workup and subsequent follow-up to treatment response.<\/jats:p>","DOI":"10.1136\/bcr-2022-251801","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T16:40:17Z","timestamp":1688575217000},"page":"e251801","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rare Extranodal Manifestation of Rosai-Dorfman Disease Presenting as Nasal Obstruction and its Management"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-6585","authenticated-orcid":false,"given":"Ting Jie","family":"Oui","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Kuala Lumpur, Malaysia"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah Dayana","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Kuala Lumpur, Malaysia"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salina","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Kuala Lumpur, Malaysia"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneeza Khairiyah","family":"Wan Hamizan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Kuala Lumpur, Malaysia"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"2025082711040646000_16.7.e251801.1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219626"},{"key":"2025082711040646000_16.7.e251801.2","doi-asserted-by":"crossref","unstructured":"MacGregor FB , Hayden J . Tumours of the head and neck in childhood. In: Scott-Brown W , Gleeson M , Browning G , eds. Scott-Brown\u2019s otolaryngology, head and neck surgery. London: Hodder Arnold, 2008. doi:10.1201\/b15118","DOI":"10.1201\/b15118"},{"key":"2025082711040646000_16.7.e251801.3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s12105-016-0719-4","article-title":"Extra nodal Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) presenting as asymmetric bilateral optic atrophy: an atypical ocular presentation","volume":"10","author":"Shukla","year":"2016","journal-title":"Head Neck Pathol"},{"key":"2025082711040646000_16.7.e251801.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197211)30:5<1174::AID-CNCR2820300507>3.0.CO;2-S"},{"key":"2025082711040646000_16.7.e251801.5","first-page":"19","article-title":"Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity","volume":"7","author":"Foucar","year":"1990","journal-title":"Semin Diagn Pathol"},{"key":"2025082711040646000_16.7.e251801.6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12070-017-1133-2","article-title":"The Rosai-Dorfman disease: a differential diagnosis in Cervical swelling","volume":"71","author":"Singh","year":"2019","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2025082711040646000_16.7.e251801.7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4103\/JLP.JLP_69_18","article-title":"Cytodiagnosis of Rosai-Dorfman disease masquerading as lymphoma: a case report with brief review of literature","volume":"10","author":"Kishore","year":"2018","journal-title":"J Lab Physicians"},{"key":"2025082711040646000_16.7.e251801.8","first-page":"56","article-title":"Role of diagnostic imaging to malignant sinus tumors in Presurgical staging","volume":"1","author":"Fanucci","year":"2008","journal-title":"Oral Implantol (Rome)"},{"key":"2025082711040646000_16.7.e251801.9","doi-asserted-by":"crossref","DOI":"10.3390\/jcm6120116","article-title":"Imaging characteristics of malignant Sinonasal tumors","volume":"6","author":"Kawaguchi","year":"2017","journal-title":"J Clin Med"},{"key":"2025082711040646000_16.7.e251801.10","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1097\/RLU.0000000000003014","article-title":"Rosai-Dorfman disease-utility of 18F-FDG PET\/CT for initial evaluation and follow-up","volume":"45","author":"Mahajan","year":"2020","journal-title":"Clin Nucl Med"},{"key":"2025082711040646000_16.7.e251801.11","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10008"},{"key":"2025082711040646000_16.7.e251801.12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/0970-9371.83473","article-title":"Extranodal manifestation of Rosai-Dorfman disease with bilateral ocular involvement","volume":"28","author":"Kala","year":"2011","journal-title":"J Cytol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:04:12Z","timestamp":1756317852000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7,5]]},"published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1136\/bcr-2022-251801"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251801","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}