{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:07Z","timestamp":1756339507193,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,3,13]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>A man with chronic obstructive pulmonary disease (COPD) in his mid-60s was admitted for respiratory failure due to multifocal, necrotising pneumonia. Despite initial improvement with antimicrobial therapy, the patient developed hemoptysis and progressive infiltrates. Subsequent fungal cultures from his bronchoalveolar lavage were positive for <jats:italic>Aspergillus niger<\/jats:italic> and treatment with voriconazole was added for suspected invasive pulmonary aspergillosis (IPA). A repeat bronchoscopy revealed cobblestone lesions with mucosal friability throughout the lower trachea and bilateral mainstem bronchi. Endobronchial biopsy showed septated hyphae confirming the diagnosis of IPA. Despite appropriate therapy, the patient declined further and passed away on hospital day 11. Invasive infections with <jats:italic>A. niger<\/jats:italic> are infrequent, with a paucity of data on clinical course and outcomes. Our case adds to the current body of literature regarding the potential virulence of this species in patients with COPD.<\/jats:p>","DOI":"10.1136\/bcr-2022-251807","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:33:12Z","timestamp":1679481192000},"page":"e251807","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Role of COPD in a case of fatal <i>Aspergillus niger<\/i> tracheobronchitis"],"prefix":"10.1136","volume":"16","author":[{"given":"Tracy","family":"Ashby","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly Marie","family":"Burcher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Louis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"2025082708181360000_16.3.e251807.1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1140\/epjc\/s10052-018-5607-5","article-title":"Search for standard model production of four top quarks with same-sign and multilepton final states in proton-proton collisions at s = 13 tev","volume":"78","author":"Sirunyan","year":"2018","journal-title":"Eur Phys J C Part Fields"},{"key":"2025082708181360000_16.3.e251807.2","doi-asserted-by":"publisher","DOI":"10.1177\/1479972307085637"},{"key":"2025082708181360000_16.3.e251807.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1988"},{"key":"2025082708181360000_16.3.e251807.4","unstructured":"Venanzi-Rullo E , Fortun-Abete J , Nunnari G . 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