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As dapsone is notorious for prolonged and rebound methaemoglobinaemia, she was managed with repeated doses of intravenous methylene blue and oral multidose activated charcoal which warranted elective intubation and intensive care unit admission. Subsequent drug-induced hepatitis and delayed dapsone-induced haemolysis were managed conservatively. She was discharged in a stable condition with outpatient follow-ups. Physician familiarity with the nuances of this rare condition and its complications contributes to better patient care.<\/jats:p>","DOI":"10.1136\/bcr-2022-251823","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T11:52:25Z","timestamp":1663674745000},"page":"e251823","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Intentional dapsone overdose: a rare cause of acquired methaemoglobinaemia in the emergency department"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-9769","authenticated-orcid":false,"given":"Sania","family":"Zia","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Rashid Hospital and Trauma Centre, Dubai Health Authority, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Nooruddin","family":"Kazim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rashid Hospital and Trauma Centre, Dubai Health Authority, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza Omer Mohammed","family":"Yousif","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rashid Hospital and Trauma Centre, Dubai Health Authority, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehraj Waheeda","family":"Kuthbudeen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rashid Hospital and Trauma Centre, Dubai Health Authority, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2025082707485904000_15.9.e251823.1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajem.2015.09.021","article-title":"Incidence and patterns of hemolytic anemia in acute dapsone overdose","volume":"34","author":"Cha","year":"2016","journal-title":"Am J Emerg Med"},{"key":"2025082707485904000_15.9.e251823.2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.0954-6820.1983.tb08597.x","article-title":"Acute dapsone intoxication: clinical findings and effect of oral charcoal and haemodialysis on dapsone elimination","volume":"214","author":"Neuvonen","year":"1983","journal-title":"Acta Med Scand"},{"key":"2025082707485904000_15.9.e251823.3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/15563657909030116","article-title":"Acute dapsone intoxication: a case with prolonged symptoms","volume":"14","author":"Elonen","year":"1979","journal-title":"Clin Toxicol"},{"key":"2025082707485904000_15.9.e251823.4","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm072"},{"key":"2025082707485904000_15.9.e251823.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000141096.00377.3f"},{"key":"2025082707485904000_15.9.e251823.6","unstructured":"Price D . 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