{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:02Z","timestamp":1756339562893,"version":"3.44.0"},"reference-count":3,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,9,6]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>A man in his 70s developed thyrotoxicosis due to painless thyroiditis after starting nivolumab, which was subsequently followed by severe hypothyroidism. We diagnosed him as chronic thyroiditis, initiated levothyroxine supplementation and treated appropriately. Retrospective CT images of the thyroid gland during the clinical course revealed that the CT attenuation value was high at first but gradually decreased. The high-density signal of the normal thyroid tissues reflects its function of concentrating inorganic iodine, and the progressive decrease of the CT density in the present case can be viewed as a reflection of the thyroid destruction and progressive loss of iodine during the clinical course of the development of chronic thyroiditis. Considering the high incidence rate of functional thyroid disease in patients treated with immune checkpoint inhibitors, CT density of the thyroid gland needs to be paid attention to as the first sign of thyroiditis in this patient population.<\/jats:p>","DOI":"10.1136\/bcr-2022-251857","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:57:41Z","timestamp":1663239461000},"page":"e251857","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Progressive loss of the thyroid tissue integrity visualised by serial CT scans"],"prefix":"10.1136","volume":"15","author":[{"given":"Hiroyuki","family":"Koyama","sequence":"first","affiliation":[{"name":"Gastroenterology and Metabolism, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Hattori","sequence":"additional","affiliation":[{"name":"Gastroenterology and Metabolism, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Gastroenterology and Metabolism, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"2025082711194323000_15.9.e251857.1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200003000-00026"},{"key":"2025082711194323000_15.9.e251857.2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s13244-016-0506-5","article-title":"Thyroid computed tomography imaging: pictorial review of variable pathologies","volume":"7","author":"Bin Saeedan","year":"2016","journal-title":"Insights Imaging"},{"key":"2025082711194323000_15.9.e251857.3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102560","article-title":"Autoimmune endocrine dysfunctions associated with cancer immunotherapies","volume":"20","author":"Ferrari","year":"2019","journal-title":"Int J Mol Sci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:19:49Z","timestamp":1756318789000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":3,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,15]]},"published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1136\/bcr-2022-251857"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251857","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}