{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:32:22Z","timestamp":1763728342331,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,10,29]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>SARS-CoV-2 is now a major global health issue and manifests mainly as a respiratory disorder. Several other complications involving hypercoagulability, cardiovascular system and central nervous system have been described in the literature. Among these atypical presentations, encephalopathy associated with SARS-CoV-2 is a rare entity with heterogenous clinical and radiological findings. The direct presence of SARS-CoV-2 in cerebrospinal fluid (CSF) was rarely found in encephalopathy patients with acute SARS-Cov-2 infection.<\/jats:p>\n               <jats:p>Here, we report a case of myeloencephalitis with positive real-time PCR for SARS-CoV-2 in CSF in a young woman presenting exclusively with neurological symptoms. Other differential diagnosis were extensively pursued by a comprehensive aetiological workup. To our knowledge, this is the first case report in the Omicron era. In the context of recent global explosion of SARS-Cov-2 infections, clinicians should consider this pathogen among other possible neurotropic agents and be familiar with its radiological and clinical presentations.<\/jats:p>","DOI":"10.1136\/bcr-2022-251922","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:37:14Z","timestamp":1668512234000},"page":"e251922","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Myeloencephalitis as the only presentation of Omicron SARS-CoV-2 infection"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-5023","authenticated-orcid":false,"given":"Tinh Quang","family":"Dang","sequence":"first","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Thien","family":"La","sequence":"additional","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai Ngoc","family":"Tran","sequence":"additional","affiliation":[{"name":"Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2025082623415589000_15.11.e251922.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30221-0"},{"key":"2025082623415589000_15.11.e251922.2","unstructured":"Worldometer . COVID-19 coronavirus pandemic, 2022. Available: https:\/\/www.worldometers.info\/coronavirus\/#countries [Accessed 12 May 2022]."},{"key":"2025082623415589000_15.11.e251922.3","doi-asserted-by":"publisher","DOI":"10.1086\/521262"},{"key":"2025082623415589000_15.11.e251922.4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117316","article-title":"Cerebrospinal fluid in COVID-19: a systematic review of the literature","volume":"421","author":"Lewis","year":"2021","journal-title":"J Neurol Sci"},{"key":"2025082623415589000_15.11.e251922.5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1515\/revneuro-2021-0082","article-title":"Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies","volume":"33","author":"Zamani","year":"2022","journal-title":"Rev Neurosci"},{"key":"2025082623415589000_15.11.e251922.6","doi-asserted-by":"crossref","unstructured":"Kato S , Yoshikura N , Kimura A , et al . Possible autoimmune encephalitis associated with the severe acute respiratory syndrome coronavirus 2 omicron variant successfully treated with steroids: a case report. Intern Med 2023.doi:10.2169\/internalmedicine.0371-22","DOI":"10.2169\/internalmedicine.0371-22"},{"key":"2025082623415589000_15.11.e251922.7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S2213-2600(20)30552-X","article-title":"Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study","volume":"9","author":"Pun","year":"2021","journal-title":"Lancet Respir Med"},{"key":"2025082623415589000_15.11.e251922.8","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14913"},{"key":"2025082623415589000_15.11.e251922.9","doi-asserted-by":"crossref","first-page":"100399","DOI":"10.1016\/j.bbih.2021.100399","article-title":"Neurological consequences of COVID-19 and brain related pathogenic mechanisms: a new challenge for neuroscience","volume":"19","author":"Sarubbo","year":"2022","journal-title":"Brain Behav Immun Health"},{"key":"2025082623415589000_15.11.e251922.10","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1111\/ene.15045","article-title":"Neuropathological findings from COVID-19 patients with neurological symptoms argue against a direct brain invasion of SARS-CoV-2: a critical systematic review","volume":"28","author":"Cosentino","year":"2021","journal-title":"Eur J Neurol"},{"key":"2025082623415589000_15.11.e251922.11","doi-asserted-by":"crossref","unstructured":"Demirci Otluoglu G , Yener U , Demir MK , et al . Encephalomyelitis associated with Covid-19 infection: case report. Br J Neurosurg 2020:1\u20133.doi:10.1080\/02688697.2020.1787342","DOI":"10.1080\/02688697.2020.1787342"},{"key":"2025082623415589000_15.11.e251922.12","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s13311-022-01267-y","article-title":"Therapeutic approaches to the neurologic manifestations of COVID-19","volume":"19","author":"Graham","year":"2022","journal-title":"Neurotherapeutics"},{"key":"2025082623415589000_15.11.e251922.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"2025082623415589000_15.11.e251922.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09866-5"},{"key":"2025082623415589000_15.11.e251922.15","unstructured":"WHO . Statement on omicron sublineage BA.2, 2022. Available: https:\/\/www.who.int\/news\/item\/22-02-2022-statement-on-omicron-sublineage-ba.2#:~:text=2.,should%20remain%20classified%20as%20Omicron [Accessed 12 May 2022]."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-251922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:42:06Z","timestamp":1756276926000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-251922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,15]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-251922"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-251922","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}