{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:40:13Z","timestamp":1756305613245,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2023,5,20]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Beh\u00e7et\u2019s disease commonly affects 20\u201340-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded to steroid and colchicine therapy. He had a history of uveitis and was homozygous for the human leucocyte antigen-B51 allele, and we clinically diagnosed him with acute neuro-Beh\u00e7et\u2019s disease. Old-age onset neuro-Beh\u00e7et\u2019s disease is uncommon, and as far as we know, this is the oldest case of the first attack of neuro-Beh\u00e7et\u2019s disease. Clinicians should consider Beh\u00e7et\u2019s disease even for elderly patients.<\/jats:p>","DOI":"10.1136\/bcr-2022-252033","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:35:49Z","timestamp":1685615749000},"page":"e252033","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Case of elderly onset possible neuro-Beh\u00e7et\u2019s disease with HLA-B51 homozygosity"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-2622","authenticated-orcid":false,"given":"Wataru","family":"Shiraishi","sequence":"first","affiliation":[{"name":"Depaartment of Neurology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Matsuyoshi","sequence":"additional","affiliation":[{"name":"Depaartment of Neurology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Depaartment of Neurology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2025082706580694000_16.6.e252033.1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0436"},{"key":"2025082706580694000_16.6.e252033.2","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s00415-013-7209-3","article-title":"Diagnosis and management of neuro-Behcet\u2019s disease: international consensus recommendations","volume":"261","author":"Kalra","year":"2014","journal-title":"J Neurol"},{"key":"2025082706580694000_16.6.e252033.3","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/rheumatology\/kex285","article-title":"Clinical manifestations of Behcet\u2019s disease depending on sex and age: results from Japanese nationwide registration","volume":"56","author":"Ishido","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"2025082706580694000_16.6.e252033.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.6.783"},{"key":"2025082706580694000_16.6.e252033.5","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/brain\/122.11.2171","article-title":"Clinical patterns of neurological involvement in Behcet\u2019s disease: evaluation of 200 patients","volume":"122 (Pt 11)","author":"Akman-Demir","year":"1999","journal-title":"Brain"},{"key":"2025082706580694000_16.6.e252033.6","first-page":"1078","article-title":"Criteria for diagnosis of Behcet\u2019s disease. 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