{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:58:00Z","timestamp":1768643880709,"version":"3.49.0"},"reference-count":24,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,14]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Thyroid mucoepidermoid carcinoma (MEC) is a rare thyroid malignancy first documented in 1977. The majority of thyroid MECs are indolent, low-grade tumours with excellent prognosis. A woman in her 60s presented with an ongoing sensation of a lump in the left neck. There were no swallowing, voice or airway concerns. Ultrasound of the neck showed an enlarged thyroid with U5 and U3 features on the right and left lobes, respectively. Right fine needle aspiration cytology (FNAC) demonstrated certain features of Hurthle cell or anaplastic carcinoma (Thy5). Left FNAC showed Hurthle cell changes with atypical cells and prominent nucleoli (Thy3a). Following total thyroidectomy, histopathology revealed synchronous right low-grade MEC and left papillary thyroid microcarcinomas (pT2(m) N0 M0) on a background of Hashimoto\u2019s thyroiditis. This case adds to the literature and details the key histopathological features for a rare but important differential in patients with thyroid carcinoma due to synchronous histological types.<\/jats:p>","DOI":"10.1136\/bcr-2022-252117","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T10:40:56Z","timestamp":1669113656000},"page":"e252117","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous mucoepidermoid carcinoma and papillary microcarcinomas of the thyroid gland"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-0001","authenticated-orcid":false,"given":"Keshav Kumar","family":"Gupta","sequence":"first","affiliation":[{"name":"Head & Neck Surgical Oncology Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Garas","sequence":"additional","affiliation":[{"name":"Head & Neck Surgical Oncology Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Wilkes","sequence":"additional","affiliation":[{"name":"Department of Histopathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mriganka","family":"De","sequence":"additional","affiliation":[{"name":"Head & Neck Surgical Oncology Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"2025082802005181000_15.11.e252117.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02303.x"},{"key":"2025082802005181000_15.11.e252117.2","unstructured":"Ellis GL , Auclair PL . AFIP atlas of tumor pathology. tumors of the salivary gland. Silver Spring: ARP Press, 2008: 173\u201396."},{"key":"2025082802005181000_15.11.e252117.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197701)39:1<210::AID-CNCR2820390133>3.0.CO;2-H"},{"key":"2025082802005181000_15.11.e252117.4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12105-020-01193-5","article-title":"Salivary-like tumors of the thyroid: a comprehensive review of three rare carcinomas","volume":"15","author":"Chambers","year":"2021","journal-title":"Head Neck Pathol"},{"key":"2025082802005181000_15.11.e252117.5","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20458"},{"key":"2025082802005181000_15.11.e252117.6","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3346\/jkms.2010.25.11.1683","article-title":"Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report","volume":"25","author":"Jung","year":"2010","journal-title":"J Korean Med Sci"},{"key":"2025082802005181000_15.11.e252117.7","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-010-9145-4"},{"key":"2025082802005181000_15.11.e252117.8","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-013-9267-6"},{"key":"2025082802005181000_15.11.e252117.9","first-page":"45","article-title":"Mucoepidermoid carcinoma of the thyroid: a case report","volume":"20","author":"Jayaram","year":"1998","journal-title":"Malays J Pathol"},{"key":"2025082802005181000_15.11.e252117.10","unstructured":"DeLellis R , Lloyd R , Heity P . WHO classification of tumours: pathology and genetics of tumours of endocrine organs. Lyon, France: International Agency for Research in Cancer Press, 2004: 82\u20133."},{"key":"2025082802005181000_15.11.e252117.11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880140"},{"key":"2025082802005181000_15.11.e252117.12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00000478-199105000-00003","article-title":"Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto's thyroiditis","volume":"15","author":"Chan","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"2025082802005181000_15.11.e252117.13","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/1097-0142(19900501)65:9<2020::AID-CNCR2820650923>3.0.CO;2-#","article-title":"Mucoepidermoid carcinoma of the thyroid gland","volume":"65","author":"Katoh","year":"1990","journal-title":"Cancer"},{"key":"2025082802005181000_15.11.e252117.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199510000-00012"},{"key":"2025082802005181000_15.11.e252117.15","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/1097-0142(19840415)53:8<1741::AID-CNCR2820530821>3.0.CO;2-C","article-title":"Primary mucoepidermoid carcinoma in the thyroid gland. A case report including an ultrastructural and biochemical study","volume":"53","author":"Mizukami","year":"1984","journal-title":"Cancer"},{"key":"2025082802005181000_15.11.e252117.16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01599.x"},{"key":"2025082802005181000_15.11.e252117.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1984.tb02400.x"},{"key":"2025082802005181000_15.11.e252117.18","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194511000-00005"},{"key":"2025082802005181000_15.11.e252117.19","first-page":"307","article-title":"Mucoepidermoid carcinoma of the thyroid gland arising from a papillary epithelial neoplasm","volume":"64","author":"Arezzo","year":"1998","journal-title":"Am Surg"},{"key":"2025082802005181000_15.11.e252117.20","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0276"},{"key":"2025082802005181000_15.11.e252117.21","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.2.175"},{"key":"2025082802005181000_15.11.e252117.22","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-236539","article-title":"Poorly differentiated mucoepidermoid carcinoma of the thyroid","volume":"13","author":"Lee","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082802005181000_15.11.e252117.23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000498917","article-title":"Primary mucoepidermoid carcinoma of the thyroid: a report of a rare case with bone metastasis and review of the literature","volume":"12","author":"Le","year":"2019","journal-title":"Case Rep Oncol"},{"key":"2025082802005181000_15.11.e252117.24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/862545","article-title":"A poor prognostic case of mucoepidermoid carcinoma of the thyroid: a case report","volume":"2012","author":"Shindo","year":"2012","journal-title":"Case Rep Endocrinol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2022-252117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:01:01Z","timestamp":1756371661000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2022-252117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,22]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bcr-2022-252117"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2022-252117","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}